Gastrin and Gastrin Sequences

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CAT# Product Name M.W Molecular Formula Inquiry
G03001 GRP (18-27) (human, porcine, canine) 1120.30 C50H73N17O11S Inquiry
G03002 Leptin (93-105), human 1527.7 Inquiry
G03003 Gastrin Releasing Peptide (1-16), porcine 1546.9 C70H115N17O20S1 Inquiry
G03004 Leptin (116-130), mouse. 1561.7 Inquiry
G03005 Gastrin Releasing Peptide (1-16), human 1600.9 C74H121N17O20S1 Inquiry
G03007 Gastrin Releasing Peptide (14-27), porcine, human 1668.0 C75H110N24O16S2 Inquiry
G03009 Gastrin-Releasing Peptide (1-17) 1757.1 Inquiry
G03010 (Leu15)-Gastrin-1, human 2080.2 Inquiry
G03011 Gastrin-1, human 2098.2 Inquiry
G03012 Gastrin derived peptide 2115.3 Inquiry
G03013 Gastrin-1, rat 2126.3 Inquiry
G03014 Gastrin-1, human, sulfated (Gastrin II) 2178.3 Inquiry
G03015 Gastrin Releasing Peptide, porcine 2805.4 C126H198N38O31S2 Inquiry
G03016 Gastrin Releasing Peptide, human 2859.3 C130H204N38O31S2 Inquiry
G03020 Gastrin, chicken 4055.6 C190H265N47O51S1 Inquiry
G03021 Gastrin Tetrapeptide, Gastrin (14-17), human 546.7 Inquiry
G03022 Gastrin Tetrapeptide 596.71 C29H36N6O6S Inquiry
G03023 Acetyl-GRP (20-26) (human, porcine, canine) 859.99 C41H57N13O8 Inquiry
G03024 Acetyl-GRP (20-27) (human, porcine, canine) 991.19 C46H66N14O9S Inquiry
G03026 Biotinyl-(Glu1)-Gastrin I (human) 2342.55 Inquiry

Introduction

Gastrins are peptide hormones secreted by G cells from the gastric antrum and duodenal mucosa. They were discovered and named in 1906 by British scholar Edkins. Post-translational processing of gastrin is a typical process of processing a prohormone into a prohormone, which is processed into a biologically active body with different functions, wherein amidated gastrin is the main product. Gastrin is a class of gastrointestinal hormones that normally promote gastric acid secretion and gastrointestinal mucosal growth by binding to corresponding receptors. Exogenous gastrin can cause the development of various tumors (including gastric cancer, intestinal cancer, pancreatic cancer, esophageal cancer, etc.) by autocrine, paracrine or endocrine methods. Gastrin has now become a target for the treatment of related tumors.

Mechanism of action

Normally, the amidoxime gastrin exerts an effect of promoting gastric acid secretion and gastric mucosal cell growth by endocrine means. The main by enterochromaffin-like cells (enterochromaffin-like cells, ECL) on CCK-B receptor (cholecystokinin B receptors, CCKBR), promoting gene expression (particularly histamine synthesis and storage related gene) and histamine secretion, and then histamine stimulates parietal cells to secrete gastric acid. Gastrin also binds to CCK-B receptors on parietal cells and promotes gastric acid secretion by causing changes in Ca2+ concentrations in parietal cells. Gastrin regulates cell growth, differentiation, and apoptosis by activating various signaling pathways, including ERK 1/2, JNK, p38-MAPK signaling pathway, and JAK2-STAT3 signaling pathway. Gastrin participates in tumor formation by activating these signaling pathways.

Application of Gastrin and Gastrin Sequences

At present, anti-gastrin has become an effective means for treating related tumors, and specific methods thereof include secretion inhibition, receptor antagonism and anti-gastrin antibody method. The main receptor for gastrin binding is CCK-R. CCK-R antagonists mainly include specific CCK-AR antagonists, specific CCK-BR antagonists, and non-specific CCK-R antagonists. Its anti-tumor effect has been confirmed in both in vitro and in vivo experiments and clinical trials. Anti-gastrin antibody methods include passive immunization and active immunization, and passive immunization includes anti-gastrin 17 polyclonal or monoclonal antibody.

References

  1. Smith, J. P, Fonkoua, L. K, & Moody, T. W. (2016). The role of gastrin and cck receptors in pancreatic cancer and other malignancies. International Journal of Biological Sciences, 12(3), 283-291.
  2. Hayakawa, Y., Chang, W., Jin, G., & Wang, T. C. (2016). Gastrin and upper gi cancers. Current Opinion in Pharmacology, 31, 31-37.
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