Pituitary Adenylate Cyclase Activating Polypeptides (PACAP) and Fragments

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CAT# Product Name M.W Molecular Formula Inquiry
P08001 [Arg14,20,21, Leu16] PACAP (1-27), human, ovine, rat 3213.7 C143H226N46O39 Inquiry
P08002 [Des-Gln16] PACAP (6-27), human, ovine, rat 2510.0 C116H185N31O29S1 Inquiry
P08003 PACAP-Related Peptide (PRP), rat 3361.9 C148H242N42O45S1 Inquiry
P08004 [Arg14,20,21, Leu16]-PACAP (1-27)-Gly-Lys-Arg, amide, human, ovine, rat 3555.1 Inquiry
P08005 PACAP 38, amide, frog 4548.4 Inquiry
P08008 PACAP-27 (human, mouse, ovine, porcine, rat) 3147.65 C142H224N40O39S Inquiry
P08009 PACAP-27 (6-27) (human, chicken, mouse, ovine, porcine, rat) 2638.13 C121H193N33O31S Inquiry
P08011 PACAP-38 (6-38) (human, chicken, mouse, ovine, porcine, rat) 4024.80 C182H300N56O45S Inquiry
P08012 PACAP-38 (16-38) (human, chicken, mouse, ovine, porcine, rat) 2720.37 C123H215N39O28S Inquiry
P08013 PACAP-38 (28-38) (human, chicken, mouse, ovine, porcine, rat) 1403.70 C61H110N24O14 Inquiry
P08014 PACAP-38 (31-38) (human, chicken, mouse, ovine, porcine, rat) 1062.28 C47H83N17O11 Inquiry

Introduction

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) is a new neuropeptide discovered by Miyata et al. in Japan in 1989. It is named for its high activation of rat pituitary cell adenylate cyclase (AC). PACAP is a polypeptide with a variety of biological activities. PACAP-38 and PACA-27 are composed of 38 and 27 amino acids, respectively. The amino acid sequence of the latter is identical to the N-terminal 1 to 27 amino acid residues of PACAp-38. PACAP is widely distributed in animals and found that PACAP and its immunologically reactive substances are widely present in the animal's nerve center and peripheral nervous system, and have a variety of important biological functions, including possible involvement in the nervous system, digestive system, respiratory system, cardiovascular system, reproductive system and other regulatory functions.

Mechanism of action

PACAP works by interacting with receptor substances in the human body. PACAP in the pancreatic ganglia controls the parasympathetic nerve, while the parasympathetic nerve plays an important role in early insulin secretion during feeding, which can enhance the direct regulation of islet B cells on blood glucose. In the pancreas and insulin-producing cells (D), there are two PACAP receptors, PAC1 and VPAC2, which regulate insulin secretion by activating the PACAP-specific receptor PAC1-R. PACAP is able to expand the secretion of insulin by the blood sugar-induced secretion. Therefore, we can see that PACAP maintains the body's sugar balance by regulating insulin secretion. PACAP inhibits LPS-induced IL-6 production by binding PAC1-R in macrophages. The specific receptor PAC1 regulates the apoptosis process of T lymphocytes and plays an important role in the body's immune response.

Application of PACAP

PACAP can regulate the sugar balance in the body by regulating the secretion of insulin. On the other hand, PACAP produces different glial cells, macrophages, lymphocytes and neutrophils in vitro and in vivo through different mechanisms. It can regulate the activity of inflammatory cells and inhibit the chemotaxis of neutrophils. Therefore PACAP can be used for diabetes as well as regulating the immune system.

References

  1. Martinez Carmen, Abad Catalina, Delgado Mario, et al. Anti-inflammatory rod in septic shock of pituitary adenylate cyclase-activating polypeptide receptor [J]. Proc Natl Acad S ci USA, 2002, 99(2), P1053-P1058.
  2. Jamen F, Puech R, Bockaert J, et al. Pituitary adenylate cyclase-activating polypeptide receptors mediating insulin secretion in rodent pancreatic islets are coupled to adenylate cyclase but not to PLC[J]. Endocrinology, 2002, 143(4), P1253-P1259.
* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).
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