Acetyl Hexapeptide-1 is a synthetic peptide composed of six amino acids, designed for use in cosmetic formulations targeting skin appearance and condition. It is widely incorporated in skincare products due to its ability to support the maintenance of skin's natural functions. Suitable for a variety of topical applications, Acetyl Hexapeptide-1 is compatible with standard formulation processes and is stable under typical cosmetic manufacturing conditions.
CAT No: CPC1615
CAS No:448944-47-6
Synonyms/Alias:Acetyl hexapeptide-1;Melitane;448944-47-6;Melitane (Acetyl Hexapeptide-1);(2S)-2-acetamido-N-[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]hexanamide;Stellight;Melitane?;Acetyl hexapeptide 1;Melitane GL 200;UNII-49ZWR266MZ;Melitane(AcetylHexapeptide-1);49ZWR266MZ;WPIQUSRULDNCKM-IFSWANACSA-N;HY-P5220;448744-47-6;DA-70500;CS-0857349;
Mechanism of Action (MOA)
Acetyl Hexapeptide-1 is a biomimetic signaling peptide that interacts with the melanocortin 1 receptor (MC1R) pathway in skin cells. By modulating α-MSH (alpha-melanocyte-stimulating hormone) activity, it influences intracellular cAMP levels, which can affect the expression of melanin-related genes. This peptide's action is limited to the cellular signaling environment, supporting the maintenance of a balanced skin tone within the physiological range.
Acetyl Hexapeptide-1 can be incorporated into various topical cosmetic formulations for targeted skin care.
- Suitable for use in facial serums and creams- Can be added to eye contour products- Compatible with daily moisturizers- Applicable in leave-on masks and lotions- May be included in pre- and post-sun care formulas- Integrates well with water-based systems
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