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Acetyl Tetrapeptide-9

CAT#
CPC1620
Synonyms/Alias
Dermican; LS-9745
CAS No.
928006-50-2
Sequence
N-Acetyl-Gln-Asp-Val-His
M.W/Mr.
539.5427
Molecular Formula
C22H33N7O9
Description
Acetyl Tetrapeptide-9 palys a role in the stimulation of basement membrane polysaccharide (lumican) and the synthesis of collagen I.
References
DERMICAN
INCIName
Acetyl Tetrapeptide-9
Storage
Common storage 2-8℃, long time storage -20℃.
Functions
Acetyl Tetrapeptide-9 promote dermal remodeling and helps achieve compact and plump the skin effect.

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Acetyl Tetrapeptide-9 stimulates in vitro the synthesis of lumican and collagen I to increase the quality of dermal ECM. Acetyl Tetrapeptide-11 boosts the synthesis of both syndecan-1 and collagen XVII in keratinocytes to reinforce global skin cohesion.

Skin ageing is a global process resulting from alterations in the level of many skin components. These modifications affect both the quality of the dermal extracellular matrix (ECM) and epidermis cohesion, inducing wrinkles and skin fragility, respectively. Proteoglycans (PGs) take a strategic part in dermis and epidermis homeostasis. The lumican plays an important role during the collagen fibre formation in the dermal ECM. In addition, syndecan are strongly implicated in keratinocyte activation and cohesion. The evolution of lumican and syndecan-1 levels with ageing was studied and a decrease in the synthesis of these two PGs was observed. Skin cohesion is alsomainly dependent on the quality of the dermo-epidermal junction (DEJ). Basal keratinocytes of the epidermis adhere to this junction via specific structures: the hemidesmosomes. One of its components, collagen XVII is very important for the cohesion between the epidermis and dermis.

Philippe Moussou, L. D., Vincent Bardey, O. F., & Yanusz Wegrowski, F. X. (2009). Counteracting aging phenomena by new pure tetrapeptides with targeted efficacy. J. Appl. Cosmetol, 27, 63-71.

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