Galanins and Galanin Message Associated Peptide (GMAP) Fragments
Home > Catalog Peptides > Galanins and Galanin Message Associated Peptide (GMAP) Fragments

If you find Creative Peptides is useful to satisfy your needs, please do not hesitate to contact us!

Galanins and Galanin Message Associated Peptide (GMAP) Fragments

Browse products name by alphabetical order:

Cat. # Product Name Price
G01018 Preprogalanin 28-67, rat Inquiry
G01009 M35 Inquiry
G01006 Leptin (57 - 74) Inquiry
G01005 GMAP (25-41), amide Inquiry
G01012 GMAP (16-41), amide Inquiry
G01019 GMAP (1-41), amide Inquiry
G01035 Galnon Inquiry
G01008 Galantide Inquiry
G01034 Galanin-Like Peptide (human) Inquiry
G01015 Galanin, rat Inquiry
G01004 Galanin Message Associated Peptide, GMAP (44 - 59), amide Inquiry
G01033 Galanin Message Associated Peptide (44-59) amide Inquiry
G01020 Galanin Like Peptide, GALP, porcine Inquiry
G01010 Galanin Like Peptide, GALP (41 - 60), human, porcine, rat Inquiry
G01021 Galanin Like Peptide (GALP), rat Inquiry

Introduction

Galanin (GAL) is a neuropeptide composed of 29 to 30 amino acids, and its N-terminus and C-terminus are glycine and alanine residues, respectively. GAL is widely distributed in the central and peripheral nervous systems and participates in various biological functions such as feeding, pain, endocrine, neuroprotection, learning and memory, and sexual and reproductive. In particular, it is closely related to the pathogenesis of Alzheimer’s disease (AD), neuronal development and regeneration, and pain sensitivity caused by nerve damage. GAL also protects nerve cells. The galanin receptor (GalR), which is GalR1, GalR2, and GalR3, respectively, belongs to the G protein-coupled receptor. The galanin-message-associated peptide (GMAP) is a peptide consisting of 59 or 60 amino acid residues immediately following galanin in pre pro-galanin. It has only been found to have a role in spinal cord injury repair and has been less studied.

Mechanism of action

As an inhibitory tempering, galanin regulates neurotransmitter release through hyperpolarization. In depression, anxiety and stress response, galanin has important regulatory effects on NE and 5-HT neurons. Studies have shown that galanin inhibits the release of NE and 5-HT from neurons in the blue spot and dorsal raphe nucleus. In hippocampus and hypothalamic slices, galanin inhibits depolarization-induced glutamate release, hyperpolarizing post-synaptic neurons, and producing endogenous anticonvulsant effects. GalR1 activation of Gi/o protein also opens G protein-coupled inward-rectifying K+ channels and promotes mitogen-activated protein kinase (MAPK) activation. GalR2 promotes a variety of intracellular pathways by transmitting signals coupled to multiple types of G proteins. The GalR3 signal coupling mechanism is similar to GalR1.

Application of Galanins and Galanin Message Associated Peptide (GMAP) Fragments

The numerous physiological functions of galanin and GalR suggest that they play important roles in a variety of related diseases such as Alzheimer's disease, epilepsy, alcoholism, diabetes, neuropathic pain, depression, and cancer. GalR can be used as a new potential drug target, bringing new solutions to the treatment of these diseases. In patients with AD, a large number of cholinergic neurons were lost and galanin expression was up-regulated. Galanin stimulates cholinergic neurons and promotes the release of acetylcholine (ACTH) from all remaining cells in the brain of patients with AD.

References
1. Millón C, Floresburgess, A. , Narváez M, Borrotoescuela, D. O. , Gago, B. , & Santín L, et al. (2017). The neuropeptides galanin and galanin (1-15) in depression-like behaviours. Neuropeptides, 64, 39-45.
2. Šìpkovà J, Kramà rikovà I, Hynie, S. , & Klenerovà  V. (2017). The galanin and galanin receptor subtypes, its regulatory role in the biological and pathological functions. Physiological Research, 66(5).

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at info@creative-peptides.com. We will endeavor to provide highly satisfying products and services.

Useful Tools

Peptide Calculator

Abbreviation List

Peptide Glossary

Follow us on:

Copyright © 2008 - Creative Peptides. All rights reserved.

USA

Address: 45-16 Ramsey Road, Shirley, NY 11967, USA

Tel: 1-631-624-4882

Fax: 1-631-614-7828

E-Mail:

Europe

Tel: 44-207-097-1828

E-Mail: