Luteinizing Hormone-Releasing Hormone (LH-RH)

Name: Luteinizing Hormone-Releasing Hormone (LH-RH)
Brand: Creative Peptides
SKU: R1892
Availability: MadeToOrder

Luteinizing hormone-releasing hormone (LHRH or Gonadotropin-releasing hormone [GnRH]) is an endogenous peptide hormone that binds the GnRH receptor, stimulating the secretion of reproductive hormones (such as luteinizing hormone [LH] and follicle-stimulating hormone [FSH]) from the pituitary gland. Analogs of GnRH are clinically used to treat hormone-dependent diseases such as prostate and breast cancer, hyperplasia, and endometriosis.

Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

CAT No: R1892

CAS No: 86073-88-3

Synonyms/Alias: 86073-88-3;PYR-HIS-TRP-SER-TYR-GLY-TRP-LEU-PRO-GLY-NH2;Salmon-gnrh;Gnrh, salmon-;Salmon-LHRH;LHRH, Salmon-;7-Trp-8-leu-LHRH;GNRH, trp(7)-leu(8)-;LHRH, Trp(7)-Leu(8)-;LHRH, tryptophyl(7)-leucine(8)-;Oxo-pro-his-trp-ser-tyr-gly-trp-leu-pro-glynh2;LHRH (salmon) acetate salt;DTXSID90873508;NMJREATYWWNIKX-XJIZABAQSA-N;DA-54905;G12357;LUTEINIZING HORMONE RELEASING HORMONE, SALMON;Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-tryptophyl-L-leucyl-L-prolyl-;

Chemical Name: 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-tryptophyl-L-leucyl-L-prolylglycinamide

Quick Inquiry Custom Peptide Synthesis

Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C60H73N15O13
M.W/Mr.	1212.3
Sequence	One Letter Code:XHWSYGWLPG Three Letter Code:H-Pyr-His-Trp-Ser-Tyr-Gly-Trp-Leu-Pro-Gly-NH2
Purity	≥95%

Long-term Storage Conditions	Soluble in DMSO
Shipping Condition	Shipped at 4°C.
InChI	InChI=1S/C60H73N15O13/c1-32(2)20-47(60(88)75-19-7-12-49(75)59(87)65-28-50(61)78)73-55(83)44(22-34-25-63-40-10-5-3-8-38(34)40)69-52(80)29-66-53(81)43(21-33-13-15-37(77)16-14-33)70-58(86)48(30-76)74-56(84)45(23-35-26-64-41-11-6-4-9-39(35)41)71-57(85)46(24-36-27-62-31-67-36)72-54(82)42-17-18-51(79)68-42/h3-6,8-11,13-16,25-27,31-32,42-49,63-64,76-77H,7,12,17-24,28-30H2,1-2H3,(H2,61,78)(H,62,67)(H,65,87)(H,66,81)(H,68,79)(H,69,80)(H,70,86)(H,71,85)(H,72,82)(H,73,83)(H,74,84)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
InChI Key	NMJREATYWWNIKX-XJIZABAQSA-N
Canonical SMILES	CC(C)CC(C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)CNC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8
Isomeric SMILES	CC(C)C[C@@H](C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)CNC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8

1. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate

2. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists

3. Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

4. cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging

5. Peptides as Active Ingredients: A Challenge for Cosmeceutical Industry

Write a review Ask a question

Featured Recommendations

Related Screening Libraries:

Peptide Drug Gene Construction and Expression Platform Peptide Screening Services High-throughput Screening Peptide Tools AI-based Peptide Drug Discovery and Structure Analysis Platform

Related Small Molecules:

Exenatide Acetate Insulin-like growth factor II Human growth hormone-releasing factor RAGE antagonist peptide Octreotide Zoptarelin doxorubicin Histrelin

Useful Tools

Peptide Calculator

Abbreviation List

Peptide Glossary

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at info@creative-peptides.com. We will endeavor to provide highly satisfying products and services.

Featured Services

Carbetocin

Carbetocin is a long-acting synthetic agonist analogue of human oxytocin, with antihemorrhagic and uterotonic activities. Upon administration, carbetocin targets, binds to and activates peripheral oxytocin receptors that are present on the smooth musculature of the uterus. This causes uterus contractions and prevents excessive bleeding after childbirth, particularly following Cesarean section, and may be used to decrease blood loss during hysteroscopic myomectomy.

Inquiry
DOTA-cyclo(RGDfK) acetate

Inquiry
Angiotensin II

Angiotensin II human (Angiotensin II) is a vasoconstrictor that mainly acts on the AT1 receptor. Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis.

Inquiry
Icatibant

Icatibant (Firazyr) is a synthetic peptidomimetic drug consisting of ten amino acids, and acts as an effective and specific antagonist of bradykinin B2 receptors. It has been approved in the EU for use in hereditary angioedema, and is under investigation for a number of other conditions in which bradykinin is thought to play a significant role.

Inquiry
GLP-1 (7-36) amide Acetate

Glucagon-like peptide-1 (GLP-1) is an incretin derived from the transcription product of the proglucagon gene. The major source of GLP-1 in the body is the intestinal L cell that secretes GLP-1 as a gut hormone. Its physiological functions include promoting insulin sensitivity, decreasing food intake by increasing satiety in brain and increasing insulin secretion from the pancreas in a glucose-dependent manner.

Inquiry
Argipressin

Vasopressin, also known as arginine vasopressin (AVP), antidiuretic hormone (ADH), or argipressin, is a neurohypophysial hormone found in most mammals. Its two primary functions are to retain water in the body and to constrict blood vessels.

Inquiry
Fertirelin Acetate

Fertirelin acetate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Inquiry
Teduglutide

Teduglutide is a polypeptide consisting of 33 amino acids. It is glucagon-like peptide-2 (GLP-2) analogue that is used for the treatment of short bowel syndrome.

Inquiry
Glucagon

Glucagon (Porcine glucagon) is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon decreases the activity of HNF-4. Glucagon increases HNF4α phosphorylation.

Inquiry
Aviptadil Acetate

Aviptadil, also known as vasoactive intestinal polypeptide (VIP), is a 28 amino acid neuropeptide that belongs to the glucagon-growth hormone-releasing factor secretion superfamily. Aviptadil acts as a potent systemic vasodilator and bronchodilator. It inhibits the proliferation of vascular and bronchial smooth muscle cells and decreases platelet aggregation. These biological effects are mediated by specific VIP receptors.

Inquiry