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Luteinizing Hormone-Releasing Hormone (LH-RH)

Luteinizing hormone-releasing hormone (LHRH or Gonadotropin-releasing hormone [GnRH]) is an endogenous peptide hormone that binds the GnRH receptor, stimulating the secretion of reproductive hormones (such as luteinizing hormone [LH] and follicle-stimulating hormone [FSH]) from the pituitary gland. Analogs of GnRH are clinically used to treat hormone-dependent diseases such as prostate and breast cancer, hyperplasia, and endometriosis.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Luteinizing Hormone-Releasing Hormone (LH-RH)(CAS 86073-88-3)

CAT No: R1892

CAS No:86073-88-3

Synonyms/Alias:86073-88-3;PYR-HIS-TRP-SER-TYR-GLY-TRP-LEU-PRO-GLY-NH2;Salmon-gnrh;Gnrh, salmon-;Salmon-LHRH;LHRH, Salmon-;7-Trp-8-leu-LHRH;GNRH, trp(7)-leu(8)-;LHRH, Trp(7)-Leu(8)-;LHRH, tryptophyl(7)-leucine(8)-;Oxo-pro-his-trp-ser-tyr-gly-trp-leu-pro-glynh2;LHRH (salmon) acetate salt;DTXSID90873508;NMJREATYWWNIKX-XJIZABAQSA-N;DA-54905;G12357;LUTEINIZING HORMONE RELEASING HORMONE, SALMON;Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-tryptophyl-L-leucyl-L-prolyl-;

Chemical Name:5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-tryptophyl-L-leucyl-L-prolylglycinamide

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C60H73N15O13
M.W/Mr.
1212.3
Sequence
One Letter Code:XHWSYGWLPG
Three Letter Code:H-Pyr-His-Trp-Ser-Tyr-Gly-Trp-Leu-Pro-Gly-NH2
Purity
≥95%
Long-term Storage Conditions
Soluble in DMSO
Shipping Condition
Shipped at 4°C.
InChI
InChI=1S/C60H73N15O13/c1-32(2)20-47(60(88)75-19-7-12-49(75)59(87)65-28-50(61)78)73-55(83)44(22-34-25-63-40-10-5-3-8-38(34)40)69-52(80)29-66-53(81)43(21-33-13-15-37(77)16-14-33)70-58(86)48(30-76)74-56(84)45(23-35-26-64-41-11-6-4-9-39(35)41)71-57(85)46(24-36-27-62-31-67-36)72-54(82)42-17-18-51(79)68-42/h3-6,8-11,13-16,25-27,31-32,42-49,63-64,76-77H,7,12,17-24,28-30H2,1-2H3,(H2,61,78)(H,62,67)(H,65,87)(H,66,81)(H,68,79)(H,69,80)(H,70,86)(H,71,85)(H,72,82)(H,73,83)(H,74,84)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
InChI Key
NMJREATYWWNIKX-XJIZABAQSA-N
Canonical SMILES
CC(C)CC(C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)CNC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8
Isomeric SMILES
CC(C)C[C@@H](C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)CNC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8

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