α-Methyl-D-tyrosine is a non-proteinogenic, D-configured tyrosine analogue in which an α-methyl substituent is introduced at the amino acid backbone, creating steric and conformational constraints relative to tyrosine. The molecule contains a primary amino group and a carboxyl group on the α-carbon framework and bears a phenolic side chain characteristic of the tyrosine family, with the α-methyl substitution functioning as a structural modification that can influence peptide incorporation and resistance to backbone-directed transformations. As a stereochemically defined amino acid analogue, it is used as a building block for peptide and peptidomimetic synthesis and as a chemical probe in structure-activity and chemical biology studies where altered backbone properties and side-chain presentation are investigated.
CAT No: CP18903
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