MM-102 is a novel potent inhibitor of MLL1/WDR5 protein-protein interaction.
CAT# | R1919 |
Chemical Structure | |
CAS | 1417329-24-8 |
Synonyms/Alias | MM-102; MM102; MM 102; HMTase Inhibitor IX |
Chemical Name | N-[bis(4-fluorophenyl)methyl]-1-[[(2S)-5-(diaminomethylideneamino)-2-[[2-ethyl-2-(2-methylpropanoylamino)butanoyl]amino]pentanoyl]amino]cyclopentane-1-carboxamide |
M.F/Formula | C35H49F2N7O4 |
M.W/Mr. | 669.8 |
Appearance | Solid powder |
Biological Activity | MM-102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM). It has been shown to block MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis. WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones. |
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