Nepidermin is a recombinant form of the naturally-occurring polypeptide human epidermal growth factor with potential epithelial regenerative and cytoprotective activities. Upon topical application, recombinant human epidermal growth factor (rhEGF) may stimulate epithelial proliferation, differentiation and migration, which may result in the acceleration of epithelial regeneration and wound healing. In addition, rhEGF may attenuate epithelial cytotoxicities related to chemotherapy and/or radiotherapy.
CAT No: R1936
CAS No:62253-63-8
Synonyms/Alias:NEPIDERMIN;62253-63-8;Human EGF;Nepidermin [INN];Epidermal growth factor (human);beta-Urogastrone (human);UNII-TZK30RF92W;MG 111;Human epidermal growth factor;CCRIS 6735;TZK30RF92W;rec EGF (human);Recombinant Human EGF Protein;DTXSID80211314;AKOS040759488;DA-52939;FR110126;TS-09867;
Chemical Name:(4S)-5-[[(2S)-1-[[(2R)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-[[2-[[(2S,3S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-4-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-3-carboxy-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[2-[[(2S)-3-carboxy-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[2-[[(2S)-3-carboxy-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2R)-2-[[(2S)-4-carboxy-2-[[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]-3-sulfanylpropanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]butanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-sulfanylpropanoyl]amino]-4-oxobutanoyl]amino]-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-5-oxopentanoic acid
α-Epidermal growth factor, human is a biologically active polypeptide that plays a pivotal role in cell signaling and regulation of cellular processes such as proliferation, differentiation, and survival. As a member of the epidermal growth factor (EGF) family, it functions by binding to the EGF receptor (EGFR), triggering a cascade of downstream signaling pathways essential to tissue development and homeostasis. Its human origin and structural characteristics make it a valuable tool for researchers investigating the molecular mechanisms underlying cellular communication and growth regulation. Owing to its specificity and potent biological activity, α-epidermal growth factor is widely utilized in various biochemical and cell biology applications that require precise modulation of EGFR-mediated responses.
Cell Signaling Research: α-EGF is extensively employed as a model ligand to study receptor tyrosine kinase activation, particularly the EGFR pathway. By providing a defined stimulus for EGFR, it enables researchers to dissect the intricacies of downstream signaling events, including the MAPK, PI3K/AKT, and JAK/STAT pathways. Such studies are fundamental for elucidating how external cues are transduced into cellular responses, offering insights into both normal physiology and dysregulated signaling observed in pathological states.
Cell Proliferation Assays: In vitro experiments frequently utilize this growth factor to stimulate the proliferation of various human and animal cell lines. Its ability to promote DNA synthesis and cell cycle progression makes it a standard supplement in assays designed to evaluate mitogenic responses or to optimize cell culture conditions. By providing a reproducible and well-characterized mitogen, α-EGF supports the development of robust experimental models for basic and applied biological research.
Receptor Binding and Kinetics Studies: Investigations into ligand-receptor interactions often rely on α-epidermal growth factor to characterize EGFR binding affinity, specificity, and signal transduction efficacy. It serves as a reference ligand in competitive binding assays, kinetic analyses, and receptor occupancy studies. These applications are critical for understanding receptor dynamics, evaluating the effects of mutations or inhibitors, and guiding the rational design of targeted molecular probes.
Tissue Engineering and Regenerative Biology: The growth-promoting properties of α-EGF are harnessed in research focused on tissue repair, organoid development, and regenerative strategies. By modulating cellular proliferation and migration, it supports protocols aiming to recapitulate epithelial tissue architecture or foster wound healing in experimental systems. Its role in these contexts is to provide a controlled stimulus that mimics physiological growth signals, thereby facilitating the study of developmental processes and regenerative mechanisms.
Protein Structure and Mechanism Analysis: Structural biology studies frequently use α-epidermal growth factor as a model to investigate protein folding, ligand-receptor interactions, and conformational changes upon binding. Its well-defined structure and biological relevance make it suitable for crystallography, NMR, and biophysical analyses. These studies contribute to a deeper understanding of protein-ligand recognition and inform the development of novel biomolecular tools for research and biotechnology.
By supporting these diverse research applications, α-epidermal growth factor, human serves as an indispensable reagent in the study of cell signaling, growth regulation, and protein interaction mechanisms, underpinning advances across cell biology, molecular pharmacology, and biotechnology.
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