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PAR-4 (1-6) (human)

PAR-4 (1-6) (human) is a minimal N-terminal motif of the protease-activated receptor used to study activation sequences and cleavage-dependent signaling. The short peptide enables high-resolution structural and kinetic analyses. Its charged residues support interaction mapping with proteolytic enzymes. Applications include substrate profiling, conformational studies, and signaling-peptide design.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
PAR-4 (1-6) (human)(CAS 225779-44-2)

CAT No: P4610

CAS No:225779-44-2

Synonyms/Alias:225779-44-2;H-GLY-TYR-PRO-GLY-GLN-VAL-OH;GYPGQV;PAR 4 (1-6);PAR 4 (1-6) (human);(2S)-2-[[(2S)-5-Amino-2-[[2-[[(2S)-1-[(2S)-2-[(2-aminoacetyl)amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-3-methylbutanoic acid;PAR-4 (1-6) (human);PAR4 (1-6) (human);CHEMBL1366167;HY-P1313;AKOS024457639;NCGC00167180-01;FP109247;CS-0029360;PAR-4 (1-6) (human) trifluoroacetate salt;H-Gly-Tyr-Pro-Gly-Gln-Val-OH; H-GYPGQV-OH;

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cGMP Peptide
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  • CMC information required for an IND
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  • Drug master files (DMF) filing
M.F/Formula
C28H41N7O9
M.W/Mr.
619.7
Sequence
One Letter Code:GYPGQV
Three Letter Code:H-Gly-Tyr-Pro-Gly-Gln-Val-OH
Biological Activity
N-terminal fragment of protease-activated receptor 4 (PAR4) that acts as a PAR4 agonist. Induces aggregation of human platelets.
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C28H41N7O9/c1-15(2)24(28(43)44)34-25(40)18(9-10-21(30)37)32-23(39)14-31-26(41)20-4-3-11-35(20)27(42)19(33-22(38)13-29)12-16-5-7-17(36)8-6-16/h5-8,15,18-20,24,36H,3-4,9-14,29H2,1-2H3,(H2,30,37)(H,31,41)(H,32,39)(H,33,38)(H,34,40)(H,43,44)/t18-,19-,20-,24-/m0/s1
InChI Key
VTCFYKYDKDAJKZ-XHOYROJHSA-N

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