Vasoactive Intestinal Peptides (VIPs)

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CAT# Product Name M.W Molecular Formula Inquiry
V02001 VIP Receptor Binding Inhibitor 1028.2 C50H77N9O12S1 Inquiry
V02002 Prepro VIP/PHM (111-122) 1242.5 C53H87N13O21 Inquiry
V02004 (Pyr-16)-VIP (16-28) (chicken) 1476.80 C67H113N17O18S Inquiry
V02006 Prepro VIP/PHM (156-170) 1679.9 C71H106N16O31 Inquiry
V02007 VIP (11-28), human, porcine, rat, ovine 2175.7 C96H171N31O24 Inquiry
V02008 VIP (10-28), human, porcine, rat, ovine 2339.1 C105H180N32O26S1 Inquiry
V02009 VIP (6-28) (human, bovine, porcine, rat) 2816.32 C126H207N37O34S Inquiry
V02010 PHM-27/PHI, human 2985.5 C135H214N34O40S1 Inquiry
V02011 VIP (4-28) (human, bovine, porcine, rat) 2986.54 C134H221N39O36S Inquiry
V02012 PHI-27 (porcine) 2995.43 C136H216N36O40 Inquiry
V02013 PHI-27 (rat) 3011.43 C136H216N36O41 Inquiry
V02014 VIP (3-28) (human, bovine, porcine, rat) 3101.63 C138H226N40O39S Inquiry
V02015 [Ala11,22,28]-VIP (human, bovine, porcine, rat) 3160.72 C139H231N43O39S Inquiry
V02016 VIP (human, bovine, porcine, rat) 3325.84 C147H238N44O42S Inquiry
V02018 [Lys1, Pro2,5,Arg3,4,Tyr6] VIP, human, porcine, rat, ovine 3467.1 C154H257N49O40S1 Inquiry
V02019 VIP (human, porcine, rat) FAM-labeled 3684.2 Inquiry
V02020 [pGlu16]-VIP (16-28), porcine 1503.83 C₆₈H₁₁₄N₁₈O₁₈S Inquiry
V02021 Biotinyl-VIP (human, mouse, rat) trifluoroacetate salt 3552.14 C₁₅₇H₂₅₂N₄₆O₄₄S₂ Inquiry
V02022 Helodermin 3732.24 C170H272N44O50 Inquiry
V02023 VIP-Lys(Biotin), human, porcine, rat 3681.33 C163H263N47O46S2 Inquiry

Introduction

Vasoactive intestinal peptide (VIP) is one of the neurotransmitters which is mainly released by intestinal neurons and is also abundant in the central nervous system (CNS), which is an important brain-gut peptide. There are also many VIP nerve fibers in the pancreas. Fat meal and vagal nerve stimulation can induce the release of VIP. The active peptide is a kind of straight chain peptide extracted from small intestinal mucosa. It is arranged as a part of glucagon and secretin, which can reduce blood pressure by vasodilation. From the hepatic artery, the visceral vessel has a strong action ability, but has no effect on the femoral artery. It has a strong promoting effect on the secretion of intestinal fluid, but it has a weak effect on the secretion of pancreas. It can inhibit the secretion of gastric juice and inhibit the contraction of digestive tract smooth muscle.

Mechanism of action

Vasoactive intestinal peptide (VIP) plays its biological role by activating two kinds of specific membrane receptors: VPAC1 and VPAC2, which belong to II G protein-coupled receptor (GPCRs). It consists of seven transmembrane α helical structures and short peptides in and out of cells. VPAC stimulated by VIP activated adenylate cyclase in a dose-dependent manner, then increased the concentration of cAMP in cells. The activation of VPAC also increased the concentration of Ca2+ and regulated the activity of phospholipase D in cells. In addition to binding to VPAC, VIP could also bind to the pituitary adenylate cyclase activating peptide (PAC1), a specific receptor, with low affinity.

Application of Vasoactive intestinal peptide (VIP)

VIP and VPAC are widely expressed and distributed in vivo and produce a variety of important biological effects, suggesting that VIP/VPAC is a valuable target molecule for drug development. Past studies have suggested that VIP is a potential therapeutic agent for asthma, impotence, stroke, chronic inflammation, neurodegenerative diseases and tumors. Among the many roles of VIP, anti-inflammatory and neuroprotection are the two most promising therapeutic areas.

Reference

  1. Tian Jikang, Jin Lan. A. (2013). Advances in the study of vasoactive intestinal peptides. Pharmaceutical Biotechnology. 20(6):560-563.
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