Caspase-2 Inhibitor Z-VDVAD-FMK

Name: Caspase-2 Inhibitor Z-VDVAD-FMK
Brand: Creative Peptides
SKU: R1111
Availability: MadeToOrder

Z-VDVAD-FMK is a synthetic peptide that irreversibly inhibits the activity of caspase-2. It attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells. Z-VDVAD-FMK can be used for both in vitro and in vivo studies.

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CAT No: R1111

CAS No: 210344-95-9

Synonyms/Alias: Z-DEVD-FMK;210344-95-9;Caspase-3 Inhibitor;C30H41FN4O12;L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester;benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone;methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate;Z-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone;Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone;Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone;N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone;methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate;MFCD23380217;Z-DEVD-fluoromethylketone;Z-DEVD-fluoromethyl ketone;specific inhibitor of caspase-3;CHEMBL3963349;SCHEMBL18328791;DTXSID00879990;CHEBI:138013;BDBM228619;EX-A1761;HB1282;US9345789, Z-DEVD-FMK;AKOS024456968;CS-3454;AC-31504;BP-23680;BS-16593;DA-68816;FA111066;HY-12466;D71045;Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-CH2F;Q60998625;benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone;N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl-ketone;Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone, >=90% (HPLC);(5S,8S,11S,14S)-methyl 14-(2-fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate;METHYL (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-{[(BENZYLOXY)CARBONYL]AMINO}-4-METHOXY-4-OXOBUTANAMIDO]-5-METHOXY-5-OXOPENTANAMIDO]-3-METHYLBUTANAMIDO]-5-FLUORO-4-OXOPENTANOATE;methyl (4S)-5-{[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino}-4-{[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanoyl]amino}-5-oxopentanoate;methyl (5S,8S,11S,14S)-14-(fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate;N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-valinamide, 1,2-dimethyl ester;

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C30H41FN4O12
M.W/Mr.	668.7
Sequence	One Letter Code:XXVX Three Letter Code:Cbz-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-CH2F
Labeling Target	Caspase-2
Application	Z-VDVAD-FMK (Caspase-2 inhibitor) is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity.
Appearance	White lyophilised solid
Purity	>98%
Activity	Inhibitor
Areas of Interest	Cell Biology Cancer

Long-term Storage Conditions	Soluble in DMSO
Solubility	-20 °C
InChI	InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
InChI Key	GBJVAVGBSGRRKN-JYEBCORGSA-N
Isomeric SMILES	CC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

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