Cathepsin K substrate
This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2,4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.
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| CAT# | P75004 |
| M.W/Mr. | 920 |
| Sequence | One Letter Code: Abz-HPGGPQ-EDDnp
Three Letter Code: Abz-His-Pro-Gly-Gly-Pro-Gln-EDDnp |
| Storage | -20°C |
References | Lecaille, F. et al. Biochem. J. 375, 307(2003). |
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