Glucagon (19-29) is also known as miniglucagon, an endogenous short peptide co-released with glucagon. Miniglucagon inhibits insulin secretion from pancreatic ß-cells in a Ca2+-dependent manner.
CAT No: R1880
CAS No: 64790-15-4
Synonyms/Alias: 64790-15-4;Glucagon (19-29), human;Miniglucagon;Glucagon (19-29);Glucagon(19-29);H-ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR-OH;Des(1-18) glucagon;Glucagon (19-29) (human, rat, porcine) trifluoroacetate salt;L-Threonine, N-(N2-(N-(N-(N-(N2-(N-(N-(N-(N2-L-alanyl-L-glutaminyl)-L-alpha-aspartyl)-L-phenylalanyl)-L-valyl)-L-glutaminyl)-L-tryptophyl)-L-leucyl)-L-methionyl)-L-asparaginyl)-;(2S,5S,8S,11S,14S,17S,20S,23S,26S)-14-((1H-indol-3-yl)methyl)-26-((S)-5-amino-2-((S)-2-aminopropanamido)-5-oxopentanamido)-5-(2-amino-2-oxoethyl)-17-(3-amino-3-oxopropyl)-23-benzyl-2-((R)-1-hydroxyethyl)-11-isobutyl-20-isopropyl-8-(2-(methylthio)ethyl)-4,7,10,13,16,19,22,25-octaoxo-3,6,9,12,15,18,21,24-octaazaoctacosanedioic acid;SVHJFTNFNMWDBS-FPLSMPAJSA-N;HY-P0150;MFCD00076518;DA-53593;FG108770;MS-32130;DB-277144;CS-0019925;G12236;H-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH; H-AQDFVQWLMNT-OH;L-Threonine,L-alanyl-L-glutaminyl-L-a-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-;
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M.F/Formula | C61H89N15O18S |
M.W/Mr. | 1352.5 |
Sequence | One Letter Code:AQDFVQWLMNT Three Letter Code:H-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH |
Appearance | White to off white powder |
Purity | > 95% |
Long-term Storage Conditions | Soluble in water, DMSO. |
Shipping Condition | RT, or blue ice upon request. |
InChI | InChI=1S/C61H89N15O18S/c1-29(2)23-40(55(87)68-39(21-22-95-7)54(86)73-43(26-47(65)80)59(91)76-50(32(6)77)61(93)94)70-56(88)42(25-34-28-66-36-16-12-11-15-35(34)36)72-53(85)38(18-20-46(64)79)69-60(92)49(30(3)4)75-58(90)41(24-33-13-9-8-10-14-33)71-57(89)44(27-48(81)82)74-52(84)37(17-19-45(63)78)67-51(83)31(5)62/h8-16,28-32,37-44,49-50,66,77H,17-27,62H2,1-7H3,(H2,63,78)(H2,64,79)(H2,65,80)(H,67,83)(H,68,87)(H,69,92)(H,70,88)(H,71,89)(H,72,85)(H,73,86)(H,74,84)(H,75,90)(H,76,91)(H,81,82)(H,93,94)/t31-,32+,37-,38-,39-,40-,41-,42-,43-,44-,49-,50-/m0/s1 |
InChI Key | SVHJFTNFNMWDBS-FPLSMPAJSA-N |
Canonical SMILES | CC(C)CC(C(=O)NC(CCSC)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)O)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C(C)N |
Isomeric SMILES | C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C)N)O |
1. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
2. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
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