SPR-741

Name: SPR-741
Brand: Creative Peptides
SKU: R1844
Availability: MadeToOrder

SPR741 is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacterial infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741.

Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

CAT No: R1844

CAS No: 1179330-52-9

Synonyms/Alias: SPR741;1179330-52-9;SPR-741;NAB741;(2S,3R)-2-acetamido-3-hydroxy-N-[(2R)-3-hydroxy-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]propan-2-yl]butanamide;NAB741 (acetate);SPR741 (NAB741);(2S,3R)-2-acetamido-3-hydroxy-N-((2R)-3-hydroxy-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((1R)-1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl)amino)propan-2-yl)butanamide;CHEMBL1631770;SCHEMBL21116156;GTPL13250;EX-A4067;HY-P1649;SPR741 (NAB741)?;DA-58055;CS-0079940;(2S,3R)-2-acetamido-3-hydroxy-N-[(1R)-2-hydroxy-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}ethyl]butanamide;

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C44H73N13O13
M.W/Mr.	992.1
Sequence	Three Letter Code:Ac-Thr-D-Ser-Dab(1)-Dab-D-Phe-Leu-Dab-Dab-Thr-(1)
Purity	>98 %

Long-term Storage Conditions	10 mM in DMSO
Shipping Condition	Room temperature
InChI	InChI=1S/C44H73N13O13/c1-22(2)19-31-40(66)52-27(11-15-45)36(62)51-29(13-17-47)39(65)57-34(23(3)59)43(69)48-18-14-30(53-42(68)33(21-58)56-44(70)35(24(4)60)49-25(5)61)38(64)50-28(12-16-46)37(63)55-32(41(67)54-31)20-26-9-7-6-8-10-26/h6-10,22-24,27-35,58-60H,11-21,45-47H2,1-5H3,(H,48,69)(H,49,61)(H,50,64)(H,51,62)(H,52,66)(H,53,68)(H,54,67)(H,55,63)(H,56,70)(H,57,65)/t23-,24-,27+,28+,29+,30+,31+,32-,33-,34+,35+/m1/s1
InChI Key	JBFNEVNUGGFPBQ-DDMCRLCFSA-N

1. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum

2. An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

3. A possible role of tachykinin-related peptide on an immune system activity of mealworm beetle, Tenebrio molitor L

4. Myotropic activity of allatostatins in tenebrionid beetles

5. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs

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