SPR741 is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacterial infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741.
CAT No: R1844
CAS No:1179330-52-9
Synonyms/Alias:SPR741;1179330-52-9;SPR-741;NAB741;(2S,3R)-2-acetamido-3-hydroxy-N-[(2R)-3-hydroxy-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]propan-2-yl]butanamide;NAB741 (acetate);SPR741 (NAB741);(2S,3R)-2-acetamido-3-hydroxy-N-((2R)-3-hydroxy-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((1R)-1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl)amino)propan-2-yl)butanamide;CHEMBL1631770;SCHEMBL21116156;GTPL13250;EX-A4067;HY-P1649;SPR741 (NAB741)?;DA-58055;CS-0079940;(2S,3R)-2-acetamido-3-hydroxy-N-[(1R)-2-hydroxy-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}ethyl]butanamide;
SPR-741 is a synthetic aminoglycoside derivative designed to function as a potentiator in antimicrobial research. Structurally related to polymyxin B nonapeptide, it is characterized by its ability to modulate the permeability of the Gram-negative bacterial outer membrane without exhibiting significant intrinsic antibacterial activity. This distinctive property has positioned SPR-741 as a valuable tool in the study of antibiotic adjuvants and combination therapies, particularly for investigations focused on overcoming multidrug resistance mechanisms in pathogenic bacteria. Its role in facilitating the uptake of otherwise impermeant antibiotics makes it highly relevant for researchers exploring strategies to enhance the efficacy of existing antimicrobial agents.
Antibiotic potentiation studies: SPR-741 is widely utilized in experimental models to evaluate its capacity to enhance the activity of various antibiotics against Gram-negative bacteria. By disrupting the integrity of the outer membrane, it enables increased penetration of co-administered antibiotics, thereby allowing for the assessment of synergistic effects. This application is especially pertinent in research focused on multidrug-resistant organisms, where the compound serves as a key component in combination regimens during in vitro susceptibility testing and mechanistic investigations.
Mechanistic studies of membrane permeability: As a membrane-permeabilizing agent, SPR-741 provides a robust platform for dissecting the molecular interactions governing bacterial envelope integrity. Researchers employ it to probe the role of lipopolysaccharides and other outer membrane constituents in resistance phenotypes. Its selective action on the outer membrane, while sparing mammalian cell membranes, supports detailed studies of bacterial physiology and the identification of new targets for antimicrobial development.
Screening of novel antibiotic candidates: The compound is instrumental in high-throughput screening assays aimed at discovering new antibiotics with improved activity against Gram-negative pathogens. By co-administering SPR-741 with experimental compounds, researchers can rapidly identify molecules whose efficacy is limited by poor membrane permeability. This approach accelerates the early-stage evaluation of chemical libraries and facilitates the prioritization of candidates for further development.
Pharmacodynamic and pharmacokinetic research: SPR-741 is incorporated into in vitro and ex vivo models to study the pharmacodynamic interactions between membrane-active adjuvants and conventional antibiotics. Its use allows for detailed characterization of dose-response relationships, time-kill kinetics, and the impact of membrane modulation on antibiotic uptake and distribution. These studies contribute to a deeper understanding of how adjuvant compounds can be optimized to improve therapeutic indices and guide rational drug design.
Resistance mechanism elucidation: The compound serves as a critical probe in elucidating the genetic and biochemical bases of resistance to membrane-targeting agents. By exposing bacterial strains to SPR-741 in combination with other antibiotics, researchers can monitor adaptive responses, identify resistance mutations, and characterize the regulatory pathways involved. This application supports the ongoing effort to anticipate and counteract emerging resistance trends in clinically relevant pathogens, thereby informing the development of next-generation antimicrobial strategies.
1. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs
4. TMEM16F and dynamins control expansive plasma membrane reservoirs
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More