SPR741 is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacterial infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741.
CAT No: R1844
CAS No: 1179330-52-9
Synonyms/Alias: SPR741;1179330-52-9;SPR-741;NAB741;(2S,3R)-2-acetamido-3-hydroxy-N-[(2R)-3-hydroxy-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]propan-2-yl]butanamide;NAB741 (acetate);SPR741 (NAB741);(2S,3R)-2-acetamido-3-hydroxy-N-((2R)-3-hydroxy-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((1R)-1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl)amino)propan-2-yl)butanamide;CHEMBL1631770;SCHEMBL21116156;GTPL13250;EX-A4067;HY-P1649;SPR741 (NAB741)?;DA-58055;CS-0079940;(2S,3R)-2-acetamido-3-hydroxy-N-[(1R)-2-hydroxy-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}ethyl]butanamide;
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M.F/Formula | C44H73N13O13 |
M.W/Mr. | 992.1 |
Sequence | Three Letter Code:Ac-Thr-D-Ser-Dab(1)-Dab-D-Phe-Leu-Dab-Dab-Thr-(1) |
Purity | >98 % |
Long-term Storage Conditions | 10 mM in DMSO |
Shipping Condition | Room temperature |
InChI | InChI=1S/C44H73N13O13/c1-22(2)19-31-40(66)52-27(11-15-45)36(62)51-29(13-17-47)39(65)57-34(23(3)59)43(69)48-18-14-30(53-42(68)33(21-58)56-44(70)35(24(4)60)49-25(5)61)38(64)50-28(12-16-46)37(63)55-32(41(67)54-31)20-26-9-7-6-8-10-26/h6-10,22-24,27-35,58-60H,11-21,45-47H2,1-5H3,(H,48,69)(H,49,61)(H,50,64)(H,51,62)(H,52,66)(H,53,68)(H,54,67)(H,55,63)(H,56,70)(H,57,65)/t23-,24-,27+,28+,29+,30+,31+,32-,33-,34+,35+/m1/s1 |
InChI Key | JBFNEVNUGGFPBQ-DDMCRLCFSA-N |
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