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    YAP-TEAD Inhibitor 1

    YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM).

    Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).
    YAP-TEAD Inhibitor 1(CAS 1659305-78-8)

    CAT No: R1804

    CAS No: 1659305-78-8

    Quick InquiryCustom Peptide Synthesis

    cGMP Peptide

    Registration of APIs CMC information required for an IND

    IND and NDA support Drug master files (DMF) filing

    Specification Technical Data Publications Customer reviews and Q&A
    Synonyms/AliasYAP-TEAD Inhibitor 1;CHEMBL3335461;1659305-78-8;EX-A7824;BDBM50497300;NSC837892;AKOS032945175;CCG-270697;NSC-837892;
    M.F/FormulaC93H144ClN23O21S2
    M.W/Mr.2019.9
    SequenceOne Letter Code:VPXXLRKXPASFCKPPE
    Three Letter Code:Ac-Val-Pro-Phe(3-Cl)-Hcy(1)-Leu-Arg-Lys-Nle-Pro-Ala-Ser-Phe-Cys(1)-Lys-Pro-Pro-Glu-NH2
    Shipping ConditionRoom temperature in continental US; may vary elsewhere.
    InChIInChI=1S/C93H144ClN23O21S2/c1-8-9-27-63-89(135)114-41-19-31-70(114)86(132)101-54(6)77(123)112-68(50-118)84(130)110-66(48-56-23-11-10-12-24-56)83(129)113-69(85(131)108-64(29-14-16-39-96)90(136)117-44-22-34-73(117)91(137)115-42-20-32-71(115)87(133)103-59(76(97)122)35-36-74(120)121)51-140-139-45-37-62(80(126)109-65(46-52(2)3)81(127)105-61(30-18-40-100-93(98)99)78(124)104-60(79(125)107-63)28-13-15-38-95)106-82(128)67(49-57-25-17-26-58(94)47-57)111-88(134)72-33-21-43-116(72)92(138)75(53(4)5)102-55(7)119/h10-12,17,23-26,47,52-54,59-73,75,118H,8-9,13-16,18-22,27-46,48-51,95-96H2,1-7H3,(H2,97,122)(H,101,132)(H,102,119)(H,103,133)(H,104,124)(H,105,127)(H,106,128)(H,107,125)(H,108,131)(H,109,126)(H,110,130)(H,111,134)(H,112,123)(H,113,129)(H,120,121)(H4,98,99,100)/t54-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,75-/m0/s1
    InChI KeyQRAZSFFSGBFSLJ-GUOWWYSESA-N

    1. Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics

    2. Uncarboxylated osteocalcin decreases insulin-stimulated glucose uptake without affecting insulin signaling and regulators of mitochondrial biogenesis in myotubes

    3. Oleic acid and glucose regulate glucagon-like peptide 1 receptor expression in a rat pancreatic ductal cell line

    4. Proinsulin C-peptide and insulin: Limited pattern similarities of interest in inter-peptide interactions but no C-peptide effect on insulin and IGF-1 receptor signaling

    5. Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

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