YAP-TEAD Inhibitor 1

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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Chemical Structure
ExplanationYAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM).
SequenceOne Letter Code: Ac-VP-{Phe(3-Cl)}-{Hcy}-LRK-{Nle}-PASFCKPPE-NH2 (Disulfide bridge:Hcy4-Cys13)
Three Letter Code: Ac-{Val}{Pro}{Phe(3-Cl)}{Hcy}{Leu}{Arg}{Lys}{Nle}{Pro}{Ala}{Ser}{Phe}{Cys}{Lys}{Pro}{Pro}{Glu}-NH2 (Disulfide bridge:Hcy4-Cys13)
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