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YAP-TEAD Inhibitor 1

YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM).

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
YAP-TEAD Inhibitor 1(CAS 1659305-78-8)

CAT No: R1804

CAS No:1659305-78-8

Synonyms/Alias:YAP-TEAD Inhibitor 1;CHEMBL3335461;1659305-78-8;EX-A7824;BDBM50497300;NSC837892;AKOS032945175;CCG-270697;NSC-837892;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C93H144ClN23O21S2
M.W/Mr.
2019.9
Sequence
One Letter Code:VPXXLRKXPASFCKPPE
Three Letter Code:Ac-Val-Pro-Phe(3-Cl)-Hcy(1)-Leu-Arg-Lys-Nle-Pro-Ala-Ser-Phe-Cys(1)-Lys-Pro-Pro-Glu-NH2
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C93H144ClN23O21S2/c1-8-9-27-63-89(135)114-41-19-31-70(114)86(132)101-54(6)77(123)112-68(50-118)84(130)110-66(48-56-23-11-10-12-24-56)83(129)113-69(85(131)108-64(29-14-16-39-96)90(136)117-44-22-34-73(117)91(137)115-42-20-32-71(115)87(133)103-59(76(97)122)35-36-74(120)121)51-140-139-45-37-62(80(126)109-65(46-52(2)3)81(127)105-61(30-18-40-100-93(98)99)78(124)104-60(79(125)107-63)28-13-15-38-95)106-82(128)67(49-57-25-17-26-58(94)47-57)111-88(134)72-33-21-43-116(72)92(138)75(53(4)5)102-55(7)119/h10-12,17,23-26,47,52-54,59-73,75,118H,8-9,13-16,18-22,27-46,48-51,95-96H2,1-7H3,(H2,97,122)(H,101,132)(H,102,119)(H,103,133)(H,104,124)(H,105,127)(H,106,128)(H,107,125)(H,108,131)(H,109,126)(H,110,130)(H,111,134)(H,112,123)(H,113,129)(H,120,121)(H4,98,99,100)/t54-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,75-/m0/s1
InChI Key
QRAZSFFSGBFSLJ-GUOWWYSESA-N

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