ω-Conotoxin GVIA

ω-Conotoxin GVIA is isolated from the venom of the fish-hunting snail Conus geographus. It has a role as a venom, a neurotoxin, a calcium channel blocker, and a marine metabolite.

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CAT#10-101-281
CAS106375-28-4
M.F/FormulaC120H182N38O43S6
M.W/Mr.3037.4
SequenceOne Letter Code: CKSXGSSCSXTSYNCCRSCNXYTKRCY (Modifications: X = Hyp, Disulfide bridge between 1 - 16, 8 - 19, 15 - 26, Tyr-27 = C-terminal amide)
three Letter Code: H-Cys1-Lys-Ser-Hyp-Gly-Ser-Ser-Cys8-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys15-Cys16-Arg-Ser-Cys19-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys26-Tyr-NH2
Hyp: hydroxyproline  (Disulfide bonds between Cys1-Cys16, Cys8-Cys19 and Cys15-Cys26)
ApplicationN-type calcium channel blocker
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