Cyclo(RGDyK)

Cyclo(RGDyK) is a cyclic derivative of RGD, potent, selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

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CAT No:R1824

CAS No:250612-42-1

Synonyms/Alias:250612-42-1;Cyclic Arg-Gly-Asp-D-Tyr-Lys;Cyclo(RGDyK) trifluoroacetate;Cyclo(RGDyK);Cyclo(RGDyK) (trifluoroacetate);Cyclo(L-arginylglycyl-L-a-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt;2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-5-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;2,2,2-trifluoroacetic acid;MFCD20134101;CycloRGDyK trifluoroacetate;AKOS032945157;BS-16781;DA-52211;HY-100563;CS-0019707;C74288;Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) trifluoroacetate;Cyclo(L-arginylglycyl-L-|A-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt;[(2S,5R,8S,11S)-8-(4-aminobutyl)-11-(3-carbamimidamidopropyl)-5-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl]acetic acid; bis(trifluoroacetic acid);2,2,2-Trifluoroacetic acid compound with 2-((2S,5R,8S,11S)-8-(4-aminobutyl)-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid (2:1);Cyclo(L-arginylglycyl-L-(1/4)?-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt

Chemical Name:2,2,2-trifluoroacetic acid compound with 2-((1Z,2S,3Z,5R,6Z,8S,9Z,11S,12Z)-8-(4-aminobutyl)-11-(3-guanidinopropyl)-3,6,9,12,15-pentahydroxy-5-(4-hydroxybenzyl)-1,4,7,10,13-pentaazacyclopentadeca-3,6,9,12,15-pentaen-2-yl)acetic acid (2:1)

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M.F/FormulaC31H43F6N9O12
SequenceThree Letter Code:cyclo[Arg-Gly-Asp-D-Tyr-Lys].2TFA
Purity>98%
Long-term Storage ConditionsDMSO : ≥ 130 mg/mL (153.35 mM)
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
InChIInChI=1S/C27H41N9O8.2C2HF3O2/c28-10-2-1-4-18-24(42)34-17(5-3-11-31-27(29)30)23(41)32-14-21(38)33-20(13-22(39)40)26(44)36-19(25(43)35-18)12-15-6-8-16(37)9-7-15;2*3-2(4,5)1(6)7/h6-9,17-20,37H,1-5,10-14,28H2,(H,32,41)(H,33,38)(H,34,42)(H,35,43)(H,36,44)(H,39,40)(H4,29,30,31);2*(H,6,7)/t17-,18-,19+,20-;;/m1../s1
InChI KeyCDDUWKKOPQABPG-WVSPKWNLSA-N
Canonical SMILESC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=C(C=C2)O)CC(=O)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O
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