Cyclo(RGDyK)

Cyclo(RGDyK) is a cyclic derivative of RGD, potent, selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R1824

CAS No:250612-42-1

Synonyms/Alias:250612-42-1;Cyclic Arg-Gly-Asp-D-Tyr-Lys;Cyclo(RGDyK) trifluoroacetate;Cyclo(RGDyK);Cyclo(RGDyK) (trifluoroacetate);Cyclo(L-arginylglycyl-L-a-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt;2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-5-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;2,2,2-trifluoroacetic acid;MFCD20134101;CycloRGDyK trifluoroacetate;AKOS032945157;BS-16781;DA-52211;HY-100563;CS-0019707;C74288;Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) trifluoroacetate;Cyclo(L-arginylglycyl-L-|A-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt;[(2S,5R,8S,11S)-8-(4-aminobutyl)-11-(3-carbamimidamidopropyl)-5-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl]acetic acid; bis(trifluoroacetic acid);2,2,2-Trifluoroacetic acid compound with 2-((2S,5R,8S,11S)-8-(4-aminobutyl)-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid (2:1);Cyclo(L-arginylglycyl-L-(1/4)?-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt;

Chemical Name:2,2,2-trifluoroacetic acid compound with 2-((1Z,2S,3Z,5R,6Z,8S,9Z,11S,12Z)-8-(4-aminobutyl)-11-(3-guanidinopropyl)-3,6,9,12,15-pentahydroxy-5-(4-hydroxybenzyl)-1,4,7,10,13-pentaazacyclopentadeca-3,6,9,12,15-pentaen-2-yl)acetic acid (2:1)

Custom Peptide Synthesis
cGMP Peptide
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  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C31H43F6N9O12
M.W/Mr.
847.7
Sequence
Three Letter Code:cyclo[Arg-Gly-Asp-D-Tyr-Lys].2TFA
Purity
>98%
Long-term Storage Conditions
DMSO : ≥ 130 mg/mL (153.35 mM)
Shipping Condition
Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
InChI
InChI=1S/C27H41N9O8.2C2HF3O2/c28-10-2-1-4-18-24(42)34-17(5-3-11-31-27(29)30)23(41)32-14-21(38)33-20(13-22(39)40)26(44)36-19(25(43)35-18)12-15-6-8-16(37)9-7-15;2*3-2(4,5)1(6)7/h6-9,17-20,37H,1-5,10-14,28H2,(H,32,41)(H,33,38)(H,34,42)(H,35,43)(H,36,44)(H,39,40)(H4,29,30,31);2*(H,6,7)/t17-,18-,19+,20-;;/m0../s1
InChI Key
CDDUWKKOPQABPG-TVSMIREGSA-N
Canonical SMILES
C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=C(C=C2)O)CC(=O)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

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