Products
Home > Cosmetic Peptides > Anti-aging > Dipeptide-4

If you find Creative Peptides is useful to satisfy your needs, please do not hesitate to contact us!

Dipeptide-4

CAT#
CPC1646
Synonyms/Alias
Phenylalanyltryptophan; L-PHENYLALANYL-L-TRYPTOPHAN
CAS No.
24587-41-5
M.W/Mr.
351
Molecular Formula
C20H21N3O3S
Description
Dipeptide-4 is a synthetic dipeptide consisting of cysteine and glycine. It is an antioxidant oligopeptide.
References
Quintescine IS
INCIName
Dipeptide-4
Storage
Common storage 2-8℃, long time storage -20℃.
Functions
Dipeptide-4 protects the skin from environmental stress and skin glycosylation, thus it helps maintain skin health and elasticity.

Useful Tools

Dipeptide-4 is a synthetic dipeptide consisting of cysteine and glycine. It is an antioxidant oligopeptide.

Plasmids containing 23S rRNA randomized at positions 2057-2063 and 2502-2507 were introduced into Escherichia coli, affording a library of clones which produced modified ribosomes in addition to the pre-existing wild-type ribosomes. These clones were screened with a derivative of puromycin, a natural product which acts as an analogue of the 3'-end of aminoacyl-tRNA and terminates protein synthesis by accepting the growing polypeptide chain, thereby killing bacterial cells. The puromycin derivative in this study contained the dipeptide p-methoxyphenylalanylglycine, implying the ability of the modified ribosomes in clones sensitive to this puromycin analogue to recognize dipeptides. Several clones inhibited by the puromycin derivative were used to make S-30 preparations, and some of these were shown to support the incorporation of dipeptides into proteins. The four incorporated species included two dipeptides (Gly-Phe (2) and Phe-Gly (3)), as well as a thiolated dipeptide analogue (4) and a fluorescent oxazole (5) having amine and carboxyl groups approximately the same distance apart as in a normal dipeptide. A protein containing both thiolated dipeptide 4 and a 7-methoxycoumarin fluorophore was found to undergo fluorescence quenching. Introduction of the oxazole fluorophore 5 into dihydrofolate reductase or green fluorescent protein resulted in quite strong enhancement of its fluorescence emission, and the basis for this enhancement was studied. The aggregate results demonstrate the feasibility of incorporating dipeptides as a single ribosomal event, and illustrate the lack of recognition of the central peptide bond in the dipeptide, potentially enabling the incorporation of a broad variety of structural analogues.

Maini, R., Dedkova, L. M., Paul, R., Madathil, M. M., Chowdhury, S. R., Chen, S., & Hecht, S. M. (2015). Ribosome-mediated incorporation of dipeptides and dipeptide analogues into proteins in vitro. Journal of the American Chemical Society, 137(35), 11206-11209.

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at info@creative-peptides.com. We will endeavor to provide highly satisfying products and services.
Customer Support & Price Inquiry
  • Please enter the code "peptides"

Useful Tools

Peptide Calculator

Abbreviation List

Peptide Glossary

Follow us on:

Copyright © 2008 - Creative Peptides. All rights reserved.

USA

Address: 45-16 Ramsey Road, Shirley, NY 11967, USA

Tel: 1-631-624-4882

Fax: 1-631-614-7828

E-Mail:

Europe

Tel: 44-207-097-1828

E-Mail: