Hexapeptide-10

Hexapeptide-10 is a synthetic peptide composed of six amino acids, designed for use in advanced skin care formulations. Recognized for its role in supporting skin structure, it is commonly incorporated into products targeting the appearance of skin firmness and smoothness. Hexapeptide-10 is suitable for a wide range of cosmetic applications, including facial creams, serums, and anti-aging formulations, and is compatible with global regulatory requirements for cosmetic ingredients.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Hexapeptide-10(CAS 146439-94-3)

CAT No: CPC1619

CAS No:146439-94-3

Synonyms/Alias:Hexapeptide-10;H-Ser-ile-lys-val-ala-val-OH;146439-94-3;Serilesine;L-Valine, L-seryl-L-isoleucyl-L-lysyl-L-valyl-L-alanyl-;Hexapeptide-10 [INCI];UNII-W9RS1K7T9I;W9RS1K7T9I;SIKVAV (acetate);L-Valine, N-(N-(N-(N2-(N-L-seryl-L-isoleucyl)-L-lysyl)-L-valyl)-L-alanyl)-;L-seryl-L-isoleucyl-L-lysyl-L-valyl-L-alanyl-L-valine;(2S)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s,3s)-2-[[(2s)-2-amino-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid;Hexapeptide-10?;SCHEMBL2119473;OFGVZFQUFJYSGS-CPDXTSBQSA-N;AKOS030573307;seryl-isoleucyl-lysyl-valyl-alanyl-valine;DS-19756;DS-017466;HY-125553;CS-0092199;C72781;Q27292509;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C28H53N7O8
M.W/Mr.
615.8
Sequence
One Letter Code:SIKVAV
Three Letter Code:H-Ser-Ile-Lys-Val-Ala-Val-OH
Functions
Hexapeptide-10 promotes the rebuilding of collagens and helps reduce fine lines and pore size. It is a firming active that strengthens the dermo-epidermal junction.

Mechanism of Action (MOA)

Hexapeptide-10 is a synthetic matrikine peptide that interacts with specific cell surface receptors to support cell-to-cell and cell-to-extracellular matrix (ECM) communication. By mimicking sequences found in laminin, Hexapeptide-10 is associated with the modulation of integrin signaling pathways, which can influence cellular adhesion and ECM organization. This peptide's activity is linked to the regulation of key proteins involved in maintaining the structural integrity of the skin's architecture.

Hexapeptide-10 is suitable for incorporation into a variety of cosmetic formulations targeting skin care.

- Facial serums for daily skin conditioning
- Lightweight emulsions such as lotions and creams
- Eye contour products for delicate skin areas
- Leave-on masks for enhanced skin care routines
- Gel-based moisturizers and hydrating products
- Sheet masks and fabric-based delivery systems

INCIName
Hexapeptide-10
InChI
InChI=1S/C28H53N7O8/c1-8-16(6)22(35-24(38)18(30)13-36)27(41)32-19(11-9-10-12-29)25(39)33-20(14(2)3)26(40)31-17(7)23(37)34-21(15(4)5)28(42)43/h14-22,36H,8-13,29-30H2,1-7H3,(H,31,40)(H,32,41)(H,33,39)(H,34,37)(H,35,38)(H,42,43)/t16-,17-,18-,19-,20-,21-,22-/m0/s1
InChI Key
OFGVZFQUFJYSGS-CPDXTSBQSA-N
References
Serilesine

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