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LXW7

LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 increases the phosphorylation of VEGFR-2 and activation of ERK1/2.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
LXW7(CAS 1313004-77-1)

CAT No: R1876

CAS No:1313004-77-1

Synonyms/Alias:LXW7;1313004-77-1;SCHEMBL15082201;H-D-Cys(1)-Gly-Arg-Gly-Asp-D-Asp-D-Val-D-Cys(1)-NH2;HY-P0178;CS-0021086;[(4S,7R,10R,13S,19S,25S)-25-amino-19-(3-carbamimidamidopropyl)-4-carbamoyl-10-(carboxymethyl)-7-isopropyl-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaazacyclohexacosan-13-yl]acetic acid;2,2'-((4S,7R,10R,13S,19S,25S)-25-Amino-4-carbamoyl-19-(3-guanidinopropyl)-7-isopropyl-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaazacyclohexacosane-10,13-diyl)diacetic acid;2-[(4S,7R,10R,13S,19S,25S)-25-amino-4-carbamoyl-10-(carboxymethyl)-19-[3-(diaminomethylideneamino)propyl]-6,9,12,15,18,21,24-heptaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacos-13-yl]acetic acid;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C29H48N12O12S2
M.W/Mr.
820.9
Sequence
One Letter Code:CGRGDDVC
Three Letter Code:H-D-Cys(1)-Gly-Arg-Gly-Asp-D-Asp-D-Val-D-Cys(1)-NH2
Purity
>98 %
Shipping Condition
Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
InChI
InChI=1S/C29H48N12O12S2/c1-12(2)22-28(53)40-17(23(31)48)11-55-54-10-13(30)24(49)35-8-18(42)37-14(4-3-5-34-29(32)33)25(50)36-9-19(43)38-15(6-20(44)45)26(51)39-16(7-21(46)47)27(52)41-22/h12-17,22H,3-11,30H2,1-2H3,(H2,31,48)(H,35,49)(H,36,50)(H,37,42)(H,38,43)(H,39,51)(H,40,53)(H,41,52)(H,44,45)(H,46,47)(H4,32,33,34)/t13-,14+,15+,16-,17-,22-/m1/s1
InChI Key
UUJIUMRQOUEUEJ-NBJCVSNRSA-N

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