PMX 53

PMX-53 is an effective c5a receptor antagonist (ic50 = 20 nm), which inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis. It also is an agonist for Mas-related gene 2 (MrgX2) in human mast cells.

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CAT#	R0880
CAS	219639-75-5
Synonyms/Alias	PMX 53;Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg
M.F/Formula	C47H65N11O7
M.W/Mr.	896.1
Sequence	FXPXWR(Modifications: Phe-1 = N-terminal Ac, X-2 = Orn, X-4 = D-Cha, Lactam bridge: Orn-2 to Arg-6 )
Labeling Target	C5a receptor
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Activity	Antagonist

CAT#	Product Name	M.W	Molecular Formula	Inquiry
R0808	Suc-Leu-Leu-Val-Tyr-AMC	763.89	C40H53N5O10	Inquiry
R0810	Suc-Leu-Tyr-AMC	551.6	C₂₉H₃₃N₃O₈	Inquiry
R0837	pep4c	1146.42	C48H91N17O13S	Inquiry
R0842	PDZ1 Domain inhibitor peptide	819.95	C38H61N9O11	Inquiry

CAT#	Product Name	M.W	Molecular Formula	Inquiry
10-101-20	Goserelin Acetate	1269.43	C59H84N18O14	Inquiry
10-101-59	Liraglutide	3751.2	C172H265N43O51	Inquiry
R1574	Octreotide	1019.24	C₄₉H₆₆N₁₀O₁₀S₂	Inquiry
10-101-139	Myrcludex B			Inquiry
10-101-285	Teduglutide	3752.08	C164H252N44O55S	Inquiry
R1847	Sermaglutide	4114	C187H291N45O59	Inquiry
R1961	Carbetocin	988.2	C45H69N11O12S	Inquiry

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Storage	-20°C
Solubility	Soluble in DMSO
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Long-term Storage Conditions	-20 °C
InChI	InChI=1S/C47H65N11O7/c1-29(59)53-37(25-30-13-4-2-5-14-30)42(61)55-36-20-11-22-50-41(60)35(19-10-23-51-47(48)49)54-44(63)39(27-32-28-52-34-18-9-8-17-33(32)34)56-43(62)38(26-31-15-6-3-7-16-31)57-45(64)40-21-12-24-58(40)46(36)65/h2,4-5,8-9,13-14,17-18,28,31,35-40,52H,3,6-7,10-12,15-16,19-27H2,1H3,(H,50,60)(H,53,59)(H,54,63)(H,55,61)(H,56,62)(H,57,64)(H4,48,49,51)
InChI Key	YOKBGCTZYPOSQM-UHFFFAOYSA-N
ShelfLife	>2 years if stored properly