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Protease-Activated Receptor-2, PAR-2 Agonist, amide

The peptide 2-furoyl-LIGRLO-NH2 showed higher potency and receptor selectivity for in vitro assays than other PAR-2-activating peptides. 2-Furoyl-LIGRLO-NH2 peptide was equally or more potent than SLIGRL-NH2 for increasing intracellular calcium in cultured human and rat PAR-2-expressing cells and significantly more potent than SLIGRL-NH2 in assays of tissue PAR-2 activity.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: X21179

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cGMP Peptide
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  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.W/Mr.
778
Sequence
One Letter Code: 2-Furoyl-LIGRLO-NH2
Three Letter Code: 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2
References
McGuire, JJ. et al. J Pharmacol Exp Ther 309, 1124 (2004).

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