S961

S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R1841

CAS No:1083433-49-1

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cGMP Peptide
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M.F/Formula
C211H297N55O71S2
M.W/Mr.
4804.13
Sequence
One Letter Code: GSLDESFYDWFERQLGGGSGGSSLEEEWAQIQCEVWGRGCPSY
Three Letter Code: Gly-Ser-Leu-Asp-Glu-Ser-Phe-Tyr-Asp-Trp-Phe-Glu-Arg-Gln-Leu-Gly-Gly-Gly-Ser-Gly-Gly-Ser-Ser-Leu-Glu-Glu-Glu-Trp-Ala-Gln-Ile-Gln-Cys-Glu-Val-Trp-Gly-Arg-Gly-Cys-Pro-Ser-Tyr (Disulfide bridge: Cys33-Cys40)
Appearance
White to off-white lyophilized solid
Purity
>97% (by HPLC)
Activity
In vitro, S961 also shows high-affinity to Rat IR and Pig IR with IC50s of 0.056 nM and 0.084 nM in PEG-assay, respectively.
Long-term Storage Conditions
Soluble in H2O
Shipping Condition
Room temperature

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