Timonacic

Timonacic is a cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities. Timonacic may induce malignant cells to revert back to an untransformed state. It may also restore contact inhibition, a phenomenon characterized by the paracrine inhibition of mitosis following the formation of a critical cell mass, presumably the result of cell-to-cell signal transfer. Timonacic may also produce antioxidant effects secondary to its release of cysteine and restoration of glutathione concentrations.

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CAT#	10-101-123
CAS	444-27-9
Background	The timonacic molecule has a biological significance; its importance arises from the fact that the thiazolidine ring is an integral part of pharmacologically active compounds like penicillins and antiradiation drugs. It plays an important role in hepatotoxicity protection, and is used as an adjuvant in the treatment of some kind of hepatic diseases, psoriasis and acne. The drug has been used as an antitumor agent through induction of reverse transformation. >> Read More
Synonyms/Alias	NSC-25855; DL-Thiazolidine-4-carboxylic acid; Thiaproline; 4-Thiazolidinecarboxylic acid; Thioproline; ATC; Norgamen
M.F/Formula	C4H7NO2S
M.W/Mr.	133.17
Sequence	H-DL-Thz-OH
Application	Acute and chronic hepatic disorders & Thimerosal intoxication
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Areas of Interest	Cardiovascular System & Diseases Pituitary & Hypothalamic Hormones
Functions	Vasopressin receptor activity

CAT#	Product Name	M.W	Molecular Formula	Inquiry
10-101-120	Perindopril Erbumine	441.61	C19H32N2O5.C4H11N	Inquiry
10-101-29	Secretin (human) Hydrochloride	3037.6	C130H220N44O40	Inquiry
10-101-35	Thymosin β4 Acetate	4963.49	C212H350N56O78S	Inquiry
10-101-52	Substance P Acetate	1347.63	C63H98N18O13S	Inquiry
10-101-99	Secretin (porcine) Hydrochloride	3037.6	C130H220N44O40	Inquiry

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Source#	Synthetic
Solubility	Soluble in DMSO, not in water
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Long-term Storage Conditions	-20 °C
Organism	Human
InChI	InChI=1S/C4H7NO2S/c6-4(7)3-1-8-2-5-3/h3,5H,1-2H2,(H,6,7)
InChI Key	DZLNHFMRPBPULJ-UHFFFAOYSA-N
BoilingPoint	350.3±37.0 °C at 760 mmHg
ShelfLife	>5 years if stored properly
References	Two sensitive voltammetric techniques (adsorptive and catalytic cathodic stripping) are described for the determination of timonacic, in the presence of copper or nickel ions, respectively. The measured peaks which correspond to the reduction or copper (I) or nickel-timonacic complexes are measured at -773 and -782 mV, respectively. The different experimental parameters have been carefully studied. The methods have been fully validated. The detection limits were 1.5 and 13.6 ng mL^-1, respectively. The methods have been applied for the determination of timonacic in pharmaceutical tablets. The obtained results have been compared statistically with those obtained from a published method. Amin, O. A. R., Belal, S. F., & Bakry, R. (2011). Adsorptive and Catalytic Cathodic Stripping Voltammetric Determination of Timonacic. Portugaliae Electrochimica Acta, 29(2), 115-125.
Melting Point	199 - 201ºC