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Timonacic

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CAT#
10-101-123
Synonyms/Alias
NSC-25855; DL-Thiazolidine-4-carboxylic acid; Thiaproline; 4-Thiazolidinecarboxylic acid; Thioproline; ATC; Norgamen
CAS No.
444-27-9
Sequence
H-DL-Thz-OH
M.W/Mr.
133.17
Molecular Formula
C4H7NO2S
Source
Synthetic
Long-term Storage Conditions
−20°C
Application
Acute and chronic hepatic disorders & Thimerosal intoxication
Description
Timonacic is a cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities. Timonacic may induce malignant cells to revert back to an untransformed state. It may also restore contact inhibition, a phenomenon characterized by the paracrine inhibition of mitosis following the formation of a critical cell mass, presumably the result of cell-to-cell signal transfer. Timonacic may also produce antioxidant effects secondary to its release of cysteine and restoration of glutathione concentrations.
Areas of Interest
Diseases diagnosis
  • Background
  • Related Products
  • References

The timonacic molecule has a biological significance; its importance arises from the fact that the thiazolidine ring is an integral part of pharmacologically active compounds like penicillins and antiradiation drugs. It plays an important role in hepatotoxicity protection, and is used as an adjuvant in the treatment of some kind of hepatic diseases, psoriasis and acne. The drug has been used as an antitumor agent through induction of reverse transformation.

CAS: 82834-16-0 (net), 107133-36-8 (erbumine)
Sequence: ---
M.W: 441.61
Molecular Formula: C19H32N2O5.C4H11N
CAS: 108153-74-8 (net)
Sequence: H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Glu-Gly-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2 hydrochloride salt
M.W: 3037.6
Molecular Formula: C130H220N44O40
CAS: 17034-35-4 (net)
Sequence: H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2 hydrochloride salt
M.W: 3037.6
Molecular Formula: C130H220N44O40
CAS: 33507-63-0 (net)
Sequence: H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate salt
M.W: 1347.63
Molecular Formula: C63H98N18O13S
CAS: 77591-33-4 (net)
Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH acetate salt
M.W: 4963.49
Molecular Formula: C212H350N56O78S

Two sensitive voltammetric techniques (adsorptive and catalytic cathodic stripping) are described for the determination of timonacic, in the presence of copper or nickel ions, respectively. The measured peaks which correspond to the reduction or copper (I) or nickel-timonacic complexes are measured at -773 and -782 mV, respectively. The different experimental parameters have been carefully studied. The methods have been fully validated. The detection limits were 1.5 and 13.6 ng mL-1, respectively. The methods have been applied for the determination of timonacic in pharmaceutical tablets. The obtained results have been compared statistically with those obtained from a published method.

Amin, O. A. R., Belal, S. F., & Bakry, R. (2011). Adsorptive and Catalytic Cathodic Stripping Voltammetric Determination of Timonacic. Portugaliae Electrochimica Acta, 29(2), 115-125.

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