Timonacic is a cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities. Timonacic may induce malignant cells to revert back to an untransformed state. It may also restore contact inhibition, a phenomenon characterized by the paracrine inhibition of mitosis following the formation of a critical cell mass, presumably the result of cell-to-cell signal transfer. Timonacic may also produce antioxidant effects secondary to its release of cysteine and restoration of glutathione concentrations.
CAT No: 10-101-123
CAS No:444-27-9
Synonyms/Alias:NSC-25855; DL-Thiazolidine-4-carboxylic acid; Thiaproline; 4-Thiazolidinecarboxylic acid; Thioproline; ATC; Norgamen
Two sensitive voltammetric techniques (adsorptive and catalytic cathodic stripping) are described for the determination of timonacic, in the presence of copper or nickel ions, respectively. The measured peaks which correspond to the reduction or copper (I) or nickel-timonacic complexes are measured at -773 and -782 mV, respectively. The different experimental parameters have been carefully studied. The methods have been fully validated. The detection limits were 1.5 and 13.6 ng mL-1, respectively. The methods have been applied for the determination of timonacic in pharmaceutical tablets. The obtained results have been compared statistically with those obtained from a published method.
Amin, O. A. R., Belal, S. F., & Bakry, R. (2011). Adsorptive and Catalytic Cathodic Stripping Voltammetric Determination of Timonacic. Portugaliae Electrochimica Acta, 29(2), 115-125.
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