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Ecallantide

CAT#

10-101-160

Synonyms/Alias

DX-88 cpd;EPI-KAL-2;Kalbitor

CAS No.

460738-38-9

Sequence

EAMHSFCAFK ADDGPCRAAH PRWFFNIFTR QCEEFIYGGC EGNQNRFESL EECKKMCTRD (Disulfide bridge: 7-57; 16-40; 32-53)

M.W/Mr.

7053.83

Molecular Formula

C305H442N88O91S8

Source

Synthetic

Application

Treatment of hereditary angioedema, Reduction of blood loss during cardiothoracic surgery [plasma kallikrein inhibitor]

Description

HAE is caused by a mutation of the C1-inhibitor gene. Defective or missing C1-inhibitor permits activation of kallikrein, a protease that is responsible for liberating bradykinin from its precursor kininogen. An excess of bradykinin leads to fluid leakage from blood vessels, causing swelling of tissues typical of HAE.Ecallantide suppresses this pathogenetic mechanism by selectively and reversibly inhibiting the activity of plasma kallikrein.

Areas of Interest

Hereditary angioedema

Storage

-20°C

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