Acetyl hexapeptide-3

Acetyl hexapeptide-3 is a synthetic peptide composed of six amino acids, designed for use in topical cosmetic formulations. Recognized for its role in supporting skin conditioning, it is commonly incorporated into anti-aging and facial care products. Acetyl hexapeptide-3 is valued for its compatibility with various formulation types and its ability to complement skin-smoothing and firming strategies in cosmetic applications. Suitable for global regulatory compliance in personal care products.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Acetyl hexapeptide-3(CAS 616204-22-9)

CAT No: HB00125

CAS No:616204-22-9

Synonyms/Alias:Argireline;616204-22-9;ARGIRELINE ACETATE;ARGRELINE ACETATE;(4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid;SCHEMBL223824;Argireline Acetate anti-aging cosmetic peptide;N-Acetyl-L-alpha-glutamyl-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide;(6S,9S,12S,15S,18S,21S)-21-Acetamido-1-amino-12-(3-amino-3-oxopropyl)-6-carbamoyl-18-(2-carboxyethyl)-9-(3-guanidinopropyl)-1-imino-15-(2-(methylthio)ethyl)-8,11,14,17,20-pentaoxo-2,7,10,13,16,19-hexaazatetracosan-24-oic acid;SCHEMBL22265244;Acetyl Hexapeptide-3(Argireline);RJZNPROJTJSYLC-LLINQDLYSA-N;EX-A6258;HY-P0033;AC8712;AKOS015994631;CS-5101;HS-2002;AC-28736;DA-50688;FA138103;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C34H60N14O12S
M.W/Mr.
889
Sequence
One Letter Code:EEMQRR
Three Letter Code:Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
Appearance
White Solid

Mechanism of Action (MOA)

Acetyl hexapeptide-3 is a synthetic signal peptide that interacts with the SNARE complex involved in neurotransmitter release at the neuromuscular junction. By modulating SNARE protein assembly, it helps to reduce the release of acetylcholine, thereby attenuating the stimulation of muscle contraction. This biochemical activity supports a relaxation effect on targeted skin areas, contributing to a smoother skin appearance within cosmetic formulations.

Acetyl hexapeptide-3 can be incorporated into various cosmetic formulations for targeted skin care solutions.

- Suitable for use in facial serums and creams
- Can be added to eye contour products
- Compatible with daily moisturizers and lotions
- Applicable in leave-on masks and overnight treatments
- Integrates well in primer and makeup base formulas
- May be included in sheet mask essences

Long-term Storage Conditions
Soluble in DMSO
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C34H60N14O12S/c1-17(49)43-20(8-11-25(51)52)29(57)47-22(9-12-26(53)54)31(59)48-23(13-16-61-2)32(60)46-21(7-10-24(35)50)30(58)45-19(6-4-15-42-34(39)40)28(56)44-18(27(36)55)5-3-14-41-33(37)38/h18-23H,3-16H2,1-2H3,(H2,35,50)(H2,36,55)(H,43,49)(H,44,56)(H,45,58)(H,46,60)(H,47,57)(H,48,59)(H,51,52)(H,53,54)(H4,37,38,41)(H4,39,40,42)/t18-,19-,20-,21-,22-,23-/m0/s1
InChI Key
RJZNPROJTJSYLC-LLINQDLYSA-N

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