Amylin (20-29) (human)

Amylin (20-29), human forms fibrils that are structurally similar to amyloid fibrils in pancreatic islets. This appears to be the most important amyloidogenic sequence in human amylin. This amino acids 20 to 29 fragment of amylin is critical to the pathogenesis of islet amyloid.

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CAT No: A12020

CAS No: 118068-30-7

Synonyms/Alias: L-seryl-L-asparagyl-L-asparagyl-L-phenylalanyl-glycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-serine

Chemical Name: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-4-amino-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoic acid

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M.F/Formula	C43H68N12O16
M.W/Mr.	1009.1
Sequence	One Letter Code: SNNFGAILSS Three-Letter Code: H-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-OH

InChI	InChI=1S/C43H68N12O16/c1-6-21(4)34(42(69)52-25(12-20(2)3)38(65)53-29(18-57)41(68)54-30(19-58)43(70)71)55-35(62)22(5)48-33(61)16-47-37(64)26(13-23-10-8-7-9-11-23)50-40(67)28(15-32(46)60)51-39(66)27(14-31(45)59)49-36(63)24(44)17-56/h7-11,20-22,24-30,34,56-58H,6,12-19,44H2,1-5H3,(H2,45,59)(H2,46,60)(H,47,64)(H,48,61)(H,49,63)(H,50,67)(H,51,66)(H,52,69)(H,53,65)(H,54,68)(H,55,62)(H,70,71)/t21-,22-,24-,25-,26-,27-,28-,29-,30-,34-/m0/s1
InChI Key	RMSCIVKVSZSEHU-ITYUDAQQSA-N
Canonical SMILES	CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CO)C(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(CO)N
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)N

1. Implications of ligand-receptor binding kinetics on GLP-1R signalling

2. Zeta-potential-changing nanoparticles conjugated with cell-penetrating peptides for enhanced transfection efficiency

3. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes

4. Myotropic activity and immunolocalization of selected neuropeptides of the burying beetle Nicrophorus vespilloides (Coleoptera: Silphidae)

5. High fat diet and GLP-1 drugs induce pancreatic injury in mice

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Related Small Molecules:

Pramlintide, Acetate [Pro25, 28, 29]-Amylin(1-37) (human), Amide

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Amylin (20-29) (human)

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