Decanoyl-Arg-Val-Lys-Arg-chloromethylketone

Name: Decanoyl-Arg-Val-Lys-Arg-chloromethylketone
Brand: Creative Peptides
SKU: R0888
Availability: MadeToOrder

Decanoyl-RVKR-CMK is highly specific, potent, irreversible, and cell-permeable competitive subtilisin/kex2p-like proprotein convertase inhibitor. It can inhibit activity of all seven convertases (pc1, pc2, pc4, pace4, pc5, pc7 and furin). It is used as a useful antiviral agent.

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CAT No: R0888

CAS No: 150113-99-8

Synonyms/Alias: Decanoyl-RVKR-CMK;150113-99-8;DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE;Dec-RVKR-CMK;Furin-IN-I;N-[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(3S)-1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]decanamide;decanoyl-Arg-Val-Lys-Arg-chloromethyl ketone;decanoyl-Arg-Val-Lys-Arg-CMK;Furin Inhibitor I;Decanoyl-Arg-Val-Lys-Arg-chloromethylketone trifluoroacetate salt;decanoyl-RVKR-chloromethylketone;GTPL11258;CHEBI:156289;AKOS024457645;DA-62736;decanoyl-Arg-Val-Lys-Arg chloromethylketone;HY-107760;CS-0029492;decanoyl-Arg-Val-Lys-Arg-chloromethyl-ketone;decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone;Decanoyl-Arg-Val-Lys-Arg-chloromethylketonetrifluoroacetatesalt;N(2)-(1-oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-lysinamide;N(2)-decanoyl-L-arginyl-L-valyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-lysinamide;

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C34H66ClN11O5
M.W/Mr.	744.4
Sequence	One Letter Code:RVKR Three Letter Code:decanoyl-Arg-Val-Lys-Arg-CH2Cl
Labeling Target	Proprotein convertase
Appearance	Crystalline solid
Purity	>98%
Activity	Inhibitor

Source#	Synthetic
Solubility	-20 °C
InChI	InChI=1S/C34H66ClN11O5/c1-4-5-6-7-8-9-10-18-28(48)43-25(17-14-21-42-34(39)40)31(50)46-29(23(2)3)32(51)45-26(15-11-12-19-36)30(49)44-24(27(47)22-35)16-13-20-41-33(37)38/h23-26,29H,4-22,36H2,1-3H3,(H,43,48)(H,44,49)(H,45,51)(H,46,50)(H4,37,38,41)(H4,39,40,42)/t24-,25-,26-,29-/m0/s1
InChI Key	NHBJTTGFHCHQHS-VZTVMPNDSA-N
Isomeric SMILES	CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)CCl
BoilingPoint	N/A
Melting Point	N/A

1. Cationic cell-penetrating peptides are potent furin inhibitors

2. Characterization of Novel P-Selectin Targeted Complement Inhibitors in Murine Models of Hindlimb Injury and Transplantation

3. Immune responses to peptides containing homocitrulline or citrulline in the DR4-transgenic mouse model of rheumatoid arthritis

4. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate

5. Myotropic activity and immunolocalization of selected neuropeptides of the burying beetle Nicrophorus vespilloides (Coleoptera: Silphidae)

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