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Decanoyl-Arg-Val-Lys-Arg-chloromethylketone

Decanoyl-RVKR-CMK is highly specific, potent, irreversible, and cell-permeable competitive subtilisin/kex2p-like proprotein convertase inhibitor. It can inhibit activity of all seven convertases (pc1, pc2, pc4, pace4, pc5, pc7 and furin). It is used as a useful antiviral agent.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R0888

CAS No:150113-99-8

Synonyms/Alias:Decanoyl-RVKR-CMK;150113-99-8;DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE;Dec-RVKR-CMK;Furin-IN-I;N-[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(3S)-1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]decanamide;decanoyl-Arg-Val-Lys-Arg-chloromethyl ketone;decanoyl-Arg-Val-Lys-Arg-CMK;Furin Inhibitor I;Decanoyl-Arg-Val-Lys-Arg-chloromethylketone trifluoroacetate salt;decanoyl-RVKR-chloromethylketone;GTPL11258;CHEBI:156289;AKOS024457645;DA-62736;decanoyl-Arg-Val-Lys-Arg chloromethylketone;HY-107760;CS-0029492;decanoyl-Arg-Val-Lys-Arg-chloromethyl-ketone;decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone;Decanoyl-Arg-Val-Lys-Arg-chloromethylketonetrifluoroacetatesalt;N(2)-(1-oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-lysinamide;N(2)-decanoyl-L-arginyl-L-valyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-lysinamide;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C34H66ClN11O5
M.W/Mr.
744.4
Sequence
One Letter Code:RVKR
Three Letter Code:decanoyl-Arg-Val-Lys-Arg-CH2Cl
Labeling Target
Proprotein convertase
Appearance
Crystalline solid
Purity
>98%
Activity
Inhibitor
Source#
Synthetic
Solubility
-20 °C
InChI
InChI=1S/C34H66ClN11O5/c1-4-5-6-7-8-9-10-18-28(48)43-25(17-14-21-42-34(39)40)31(50)46-29(23(2)3)32(51)45-26(15-11-12-19-36)30(49)44-24(27(47)22-35)16-13-20-41-33(37)38/h23-26,29H,4-22,36H2,1-3H3,(H,43,48)(H,44,49)(H,45,51)(H,46,50)(H4,37,38,41)(H4,39,40,42)/t24-,25-,26-,29-/m0/s1
InChI Key
NHBJTTGFHCHQHS-VZTVMPNDSA-N
Isomeric SMILES
CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)CCl
BoilingPoint
N/A
Melting Point
N/A

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