Endothelin-1 (human, bovine, dog, mouse, porcine, rat) Acetate

Endothelin-1, a 21-amino acid peptide from vascular endothelial cells of different mammalian species, is one of the most potent vasoconstrictors. ET-1 exerts a wide variety of effects on both vascular and non-vascular (e.g. heart, lung, brain) tissues. Also ET-1 plays a central role in lung fibrosis.

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CAT#10-101-82
CAS117399-94-7 (net)
Background

Endothelin-1 (ET-1) is a vasoconstrictor secreted by endothelial cells, which acts as the natural counterpart of the vasodilator nitric oxide (NO). ET-1 contributes to vascular tone and regulates cell proliferation through activation of ETA and ETB receptors. Physical factors such as shear stress, or stimuli including thrombin, epinephrine, angiotensin II, growth factors, cytokines and free radicals enhance secretion of ET-1. By contrast, mediators like nitric oxide (NO), cyclic GMP, atrial natriuretic peptide, and prostacyclin reduce the release of endogenous ET-1. Thus, under normal conditions, the effects of the ET-1 are carefully regulated through inhibition or stimulation of ET-1 release from endothelium.  >> Read More

Synonyms/AliasET-1; Endothelin-1; Endothelin1; Endothelin 1
Chemical Nameacetic acid;3-[[2-[[2-[[31-amino-7-(4-aminobutyl)-39-benzyl-4-(2-carboxyethyl)-10-(carboxymethyl)-19,22,28-tris(hydroxymethyl)-42-[(4-hydroxyphenyl)methyl]-16-(2-methylpropyl)-13-(2-methylsulfanylethyl)-3,6,9,12,15,18,21,24,27,30,38,41,44,47-tetradecaoxo-45-propan-2-yl-33,34,49,50-tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecazabicyclo[23.22.4]henpentacontane-36-carbonyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-[[1-[[1-[[1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
M.F/FormulaC109H159N25O32S5
M.W/Mr.2491.94
SequenceOne Letter Code: CSCSSLMDKECVYFCHLDXXW
Three Letter Code: H-DL-Cys(1)-DL-Ser-DL-Cys(2)-DL-Ser-DL-Ser-DL-Leu-DL-Met-DL-Asp-DL-Lys-DL-Glu-DL-Cys(2)-DL-Val-DL-Tyr-DL-Phe-DL-Cys(1)-DL-His-DL-Leu-DL-Asp-DL-xiIle-DL-xiIle-DL-Trp-OH.CH3CO2H
Labeling TargetEndothelin Receptor
ApplicationEndothelin-1 is one of the most potent vasoconstrictors.
Areas of InterestCardiovascular System & Diseases
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