Felypressin is a Vasopressin 1 agonist, and will thus have effects at all Arginine vasopressin receptor 1As. It physiologically effects on vascular SMC's due to the form in which it is administered. Its receptors are found in various sites around the body. The major points include the CNS, Liver, Anterior Pituitary, Muscle (both vascular and non-vascular smooth muscle), and Platelets (CLAMP).
CAT No: 10-101-84
CAS No:56-59-7 (net)
Synonyms/Alias:Felypressin Acetate;914453-97-7;acetic acid;N-[6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13,16-dibenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide;PLV-2 acetate;DA-53145;F88157;
Chemical Name:acetic acid;N-[6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13,16-dibenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
Felypressin Acetate is a synthetic peptide analog of vasopressin, engineered to mimic the biological activity of natural vasopressor hormones. As a nonapeptide, it features a unique structural arrangement that enables selective interaction with vascular smooth muscle receptors, leading to vasoconstrictive effects. Its chemical stability and well-defined peptide sequence make it a valuable tool for researchers exploring peptide hormone functions, vascular physiology, and receptor signaling pathways. Owing to its distinct pharmacological profile, Felypressin Acetate has become an important compound in peptide research and related biochemical investigations.
Peptide hormone signaling studies: Felypressin Acetate serves as a robust model for investigating the molecular mechanisms of peptide hormone-receptor interactions, particularly those involving vasopressin and its analogs. Researchers utilize it to dissect the structural determinants that govern receptor selectivity and downstream signaling events in vascular tissues. By employing this peptide in in vitro and ex vivo systems, scientists gain insights into the modulation of G protein-coupled receptor pathways and the physiological consequences of peptide-mediated vasoconstriction.
Vascular pharmacology research: The compound is widely used in experimental studies focused on vascular tone regulation and the contractile responses of smooth muscle. Its ability to induce vasoconstriction allows researchers to quantify the responsiveness of isolated blood vessels and to characterize the pharmacodynamics of vasopressor agents. Such investigations are fundamental for understanding the biochemical basis of blood flow regulation, vascular resistance, and the role of peptide agonists in cardiovascular homeostasis.
Peptide synthesis and structure-activity relationship (SAR) analysis: Felypressin Acetate is frequently employed as a reference standard in the synthesis and analytical evaluation of novel peptide analogs. By comparing the biological activities of modified sequences to those of Felypressin, researchers can elucidate critical structure-activity relationships that inform the rational design of new peptide drugs. This application is particularly relevant for medicinal chemistry programs aiming to optimize peptide stability, receptor affinity, or selectivity.
Analytical method development: The defined sequence and physicochemical properties of Felypressin Acetate make it a suitable calibrant or control in the development and validation of analytical techniques for peptide detection and quantification. Laboratories leverage its consistent behavior in chromatographic and mass spectrometric assays to establish sensitivity, reproducibility, and specificity parameters. Such methodological advancements support high-quality peptide analysis in both research and quality control environments.
Receptor binding and ligand screening assays: Felypressin Acetate is utilized in receptor binding studies to characterize the affinity and selectivity of vasopressin receptor subtypes. By serving as a ligand in radioligand binding or fluorescence-based assays, it enables the screening of novel receptor modulators and the mapping of binding sites. These experiments contribute to a deeper understanding of receptor pharmacology and facilitate the identification of new molecular probes for peptide hormone systems.
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