Foxy-5 has been used in trials studying the treatment of Prostate Cancer, Colorectal Cancer, Metastatic Colon Cancer, Metastatic Breast Cancer, and Metastatic Prostate Cancer.
CAT No: R1861
CAS No:881188-51-8
Synonyms/Alias:FOXY-5;881188-51-8;FOXY5;Foxy 5;N-Formyl-Met-Asp-Gly-Cys-Glu-Leu;WNT-5A derived hexapeptide FOXY-5;CBZ9UL0ARB;UNII-CBZ9UL0ARB;L-Leucine,N-formyl-L-methionyl-L-a-aspartylglycyl-L-cysteinyl-L-a-glutamyl-;L-Leucine, N-formyl-L-methionyl-L-alpha-aspartylglycyl-L-cysteinyl-L-alpha-glutamyl-;(2S)-2-[[(2S)-4-carboxy-2-[[(2R)-2-[[2-[[(2S)-3-carboxy-2-[[(2S)-2-formamido-4-methylsulfanylbutanoyl]amino]propanoyl]amino]acetyl]amino]-3-sulfanylpropanoyl]amino]butanoyl]amino]-4-methylpentanoic acid;(2S,5S,8R,14S)-5-(2-carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butanamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecanedioic acid;L-LEUCINE, N-FORMYL-L-METHIONYL-L-.ALPHA.-ASPARTYLGLYCYL-L-CYSTEINYL-L-.ALPHA.-GLUTAMYL-;Wnt5a hexapeptide;(2S)-2-((2S)-4-carboxy-2-((2R)-2-(2-((2S)-3-carboxy-2-((2S)-2-formamido-4-(methylsulfanyl)butanamido)propanamido)acetamido)-3-sulfanylpropanamido)butanamido)-4-methylpentanoic acid;(2S)-2-[(2S)-4-carboxy-2-[(2R)-2-{2-[(2S)-3-carboxy-2-[(2S)-2-formamido-4-(methylsulfanyl)butanamido]propanamido]acetamido}-3-sulfanylpropanamido]butanamido]-4-methylpentanoic acid;Foxy 5 TFA;FOXY 5 [WHO-DD];FOXY-5 [WHO-DD];Foxy-5(Wnt5a peptide mimetic);CHEMBL4297281;SCHEMBL23477401;formyl-Met-Asp-Gly-Cys-Glu-Leu;Foxy-5(Wnt5a peptide mimetic)?;CHEBI:125492;Wnt-5a Mimic Hexapeptide Foxy-5;EX-A4066;HY-P1416;AKOS025147366;CCG-208076;DB13034;DA-73540;CS-0033287;NS00072887;BRD-K13005598-001-01-5;BRD-K13005598-001-02-3;Q27216112;
Foxy-5 is a synthetic peptide that functions as a Wnt-5a mimetic, specifically designed to emulate the biological activity of the endogenous Wnt-5a protein. As a member of the Wnt signaling pathway modulators, Foxy-5 plays a crucial role in non-canonical Wnt signaling, influencing a range of cellular processes such as migration, polarity, and differentiation. Its unique sequence and structural features enable it to selectively activate Wnt-5a-dependent signaling cascades without engaging the canonical β-catenin pathway, making it a valuable molecular tool for dissecting Wnt-mediated mechanisms in various biological contexts. The compound's ability to modulate cell behavior through well-characterized signaling axes has established its relevance in developmental biology, cancer research, and cell signaling studies.
Signal transduction research: Foxy-5 is widely utilized to investigate non-canonical Wnt signaling dynamics in cellular systems. By selectively activating Wnt-5a-like pathways, it allows researchers to delineate the downstream effectors and molecular events associated with planar cell polarity and calcium signaling. This specificity enables detailed examination of how alternative Wnt pathways regulate cytoskeletal reorganization, migration, and cellular responses independent of β-catenin activation, providing critical insights into the complexity of Wnt signal transduction.
Cancer cell migration and invasion studies: The peptide is frequently employed as an experimental tool to study the impact of Wnt-5a signaling on tumor cell motility and invasiveness. In vitro assays using Foxy-5 have enabled researchers to model the suppressive effects of non-canonical Wnt activity on metastatic phenotypes. By mimicking the endogenous ligand's role in modulating cell adhesion and directional migration, it facilitates mechanistic investigations into the molecular basis of metastasis and the identification of signaling intermediates that govern cancer cell dissemination.
Developmental biology applications: As Wnt-5a signaling is pivotal during embryonic development, Foxy-5 serves as a surrogate ligand for probing morphogenetic events and tissue patterning processes. Its application in developmental models has helped clarify the contributions of non-canonical Wnt cues to axis formation, organogenesis, and cellular differentiation. The ability to selectively manipulate these pathways with a synthetic peptide enhances experimental control and reproducibility in studies of early developmental signaling networks.
Receptor-ligand interaction analysis: Foxy-5 provides a defined reagent for examining the binding specificity and functional outcomes of Wnt-5a receptor engagement. By applying the peptide in receptor binding assays or cell-based functional studies, researchers can characterize the affinity, selectivity, and downstream signaling profiles of Frizzled and related receptors. These insights are instrumental for mapping receptor-ligand relationships and for the development of targeted modulators of Wnt signaling.
Peptide-based assay development: Due to its stability and selective activity, Foxy-5 is suitable for incorporation into biochemical and cell-based assay platforms designed to monitor Wnt-5a pathway activation. Its use as a positive control or reference agonist in high-throughput screening facilitates the identification of novel modulators, inhibitors, or pathway components. The peptide's well-defined mechanism of action ensures reliable and reproducible assay performance, supporting both basic research and early-stage drug discovery initiatives focused on Wnt signaling.
2. Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors
4. Cationic cell-penetrating peptides are potent furin inhibitors
5. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More