Human PD-L1 inhibitor V

Name: Human PD-L1 inhibitor V
Brand: Creative Peptides
SKU: X21209
Availability: MadeToOrder

Programed cell death protein 1 (PD-1) is a cell surface receptor. PD-1 and its ligand PD-L1 are crucial immune checkpoints to downregulate T cell activation, tolerance and immunopathology. Several types of cancer cells overexpress PD-L1 in order to escape from the PD-1/PD-L1 immunosurveillance mechanism.
Human PD-L1 inhibitor V is a peptide-based molecule. It binds to human PD-1 and inhibits PD-1/PD-L1 binding. This peptide, hPDL-1 inhibitor V has anchor residues (underlined), LDYVNRRKMYQ that influence binding of hPD-L1 to hPD-1. Developing inhibitors specifically blocking the PD-1/PD-L1 pathway has become a popular approach toward cancer treatment.

Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

CAT No: X21209

Synonyms/Alias: Human PD-L1 inhibitor V;CHEMBL5276309;2815311-61-4;

Quick Inquiry Custom Peptide Synthesis

Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C65H104N20O18S
M.W/Mr.	1485.7
Sequence	One Letter Code:LDYVNRRKMYQ Three Letter Code:H-Leu-Asp-Tyr-Val-Asn-Arg-Arg-Lys-Met-Tyr-Gln-OH

InChI	InChI=1S/C65H104N20O18S/c1-33(2)28-39(67)53(92)81-48(32-51(90)91)60(99)83-46(30-36-15-19-38(87)20-16-36)61(100)85-52(34(3)4)62(101)84-47(31-50(69)89)59(98)78-42(12-9-26-75-65(72)73)56(95)77-41(11-8-25-74-64(70)71)55(94)76-40(10-6-7-24-66)54(93)79-43(23-27-104-5)57(96)82-45(29-35-13-17-37(86)18-14-35)58(97)80-44(63(102)103)21-22-49(68)88/h13-20,33-34,39-48,52,86-87H,6-12,21-32,66-67H2,1-5H3,(H2,68,88)(H2,69,89)(H,76,94)(H,77,95)(H,78,98)(H,79,93)(H,80,97)(H,81,92)(H,82,96)(H,83,99)(H,84,101)(H,85,100)(H,90,91)(H,102,103)(H4,70,71,74)(H4,72,73,75)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,52-/m0/s1
InChI Key	TWQFYTLFODMZIW-WIRYOQIKSA-N
References	1. Bardhan K., et.al, Front Immunol 7(550), (2016); 2. Li Q., et.al, Oncotarget 7(40), 64967-64976 (2016); 3. D'Errico G., et.al, Clin Transl Med 6(1), 3-12 (2017)

1. High fat diet and GLP-1 drugs induce pancreatic injury in mice

2. Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes

3. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die

4. Implications of ligand-receptor binding kinetics on GLP-1R signalling

5. Glucagonlike peptide 2 analogue teduglutide: stimulation of proliferation but reduction of differentiation in human Caco-2 intestinal epithelial cells

Write a review Ask a question

Useful Tools

Peptide Calculator

Abbreviation List

Peptide Glossary

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at info@creative-peptides.com. We will endeavor to provide highly satisfying products and services.

Featured Services

Deslorelin

Deslorelin is a gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen). It is currently approved for use in veterinary medicine and is used to induce ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland.

Inquiry
Teriparatide Acetate

Teriparatide(recombinant human parathyroid hormone) /PTH (1-34) (human) corresponds to the N-terminal part of human parathyroid hormone, a peptide consisting of 84 amino acids.

Inquiry
DOTA-cyclo(RGDfK) acetate

Inquiry
Somatostatin

Somatostatin is a tetradecapeptide which can suppress the growth hormone (GH) secretion and control the pituitary hormone secretion in human CNS.

Inquiry
Fertirelin Acetate

Fertirelin acetate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Inquiry
Antide

Antide acetate (Ac-AA10-NH2) is an LHRH antagonist and represses LH and FSH release from the pituitary gland. It shows a high antiovulatory activity and releases negligible histamine.

Inquiry
Buserelin Acetate

Buserelin Acetate is an agonist of gonadotropin-releasing hormone receptor(GnRHR). Buserelin is a synthetic luteinizing hormone–releasing hormone (LHRH) analog.

Inquiry
Terlipressin

Terlipressin is a synthetic triglycyllysine derivative of vasopressin with vasoconstrictive, antihemorrhagic, and antidiuretic properties. Upon intravenous administration, terlipressin, an inactive prodrug, is biotransformed to its active moiety, lysine vasopressin (LVP), a nonselective vasopressin analogue with affinity for vasopressin receptors V1 (V1a), V2 and V3 (V1b). As a V1 agonist, terlipressin increases systemic vascular resistance, particularly in the splanchnic area, resulting in a decrease of portal pressure. V1 binding also promotes platelet aggregation and glycogenolysis, while V3 binding induces adrenocorticotropic hormone (ACTH) secretion. Compared to vasopressin, terlipressin has a minimal effect on V2 receptors, which are responsible for promotion of water reabsorption in the collecting ducts of the kidney via stimulation of cyclic AMP production.

Inquiry
Teduglutide

Teduglutide is a polypeptide consisting of 33 amino acids. It is glucagon-like peptide-2 (GLP-2) analogue that is used for the treatment of short bowel syndrome.

Inquiry
Glucagon

Glucagon (Porcine glucagon) is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon decreases the activity of HNF-4. Glucagon increases HNF4α phosphorylation.

Inquiry