Orexin A human, rat, mouse, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A human, rat, mouse has a role in the regulation of feeding behavior. Orexin A human, rat, mouse is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
CAT No: HB00084
CAS No:205640-90-0
Synonyms/Alias:Orexin A;orexin-A;Orexine A;UNII-8RDY08V4VC;8RDY08V4VC;205599-75-3;Orexin A (human, rat, mouse);Oroxin-A;HB2937;C152H243N47O44S4;G13387;XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL (modifications: C-terminal amide; X-1 = Glp; Disulfide bonds: 6-12, 7-14);
Orexin A, human, is a neuropeptide derived from the hypothalamus that plays a pivotal role in regulating arousal, wakefulness, and appetite. As a member of the orexin/hypocretin family, it is characterized by its unique structure and high affinity for orexin receptors OX1R and OX2R. This peptide has garnered significant interest in the scientific community due to its involvement in diverse physiological processes, particularly those associated with sleep-wake cycles, energy homeostasis, and neuroendocrine regulation. The availability of synthetic Orexin A, human, has enabled researchers to explore its multifaceted functions in both in vitro and in vivo models, facilitating a deeper understanding of the molecular mechanisms underlying neural signaling pathways.
Neuroscience Research: Orexin A, human, serves as a valuable tool for elucidating the complex mechanisms of neuronal communication and synaptic plasticity within the central nervous system. By applying it to cultured neurons or brain slices, researchers can investigate its direct effects on neuronal excitability, neurotransmitter release, and network synchronization. The peptide's interaction with orexin receptors allows for detailed studies on how it modulates neural circuits implicated in arousal, reward, and motivation, providing insights that may inform the development of novel interventions for neurological disorders.
Sleep-Wake Regulation Studies: As a potent modulator of sleep architecture, Orexin A is extensively utilized in experimental models to dissect the molecular and cellular basis of sleep regulation. Administration of the peptide enables scientists to observe its influence on sleep latency, REM and non-REM sleep phases, and overall vigilance states. Through these studies, the peptide aids in unraveling the pathways by which orexinergic signaling maintains wakefulness and prevents excessive sleepiness, contributing to a broader understanding of circadian biology and the homeostatic control of sleep.
Metabolic and Energy Balance Investigations: The role of Orexin A in appetite regulation and energy metabolism is a focal point for metabolic research. Application of the peptide in animal models or cell cultures allows for the assessment of its impact on feeding behavior, glucose utilization, and lipid metabolism. By modulating orexinergic activity, researchers can explore the connections between central nervous system signaling and peripheral metabolic responses, shedding light on the neurobiological basis of obesity, diabetes, and related metabolic disorders.
Behavioral Pharmacology: Orexin A, human, is instrumental in behavioral studies aimed at deciphering the neurochemical substrates of motivation, reward, and addiction. Its administration in preclinical models facilitates the examination of how orexinergic pathways influence reinforcement learning, stress responses, and substance-seeking behaviors. These investigations contribute to the identification of potential molecular targets for the modulation of maladaptive behaviors and the development of therapeutic strategies for neuropsychiatric conditions.
Neuroendocrine Function Analysis: The peptide is also employed in research focused on the regulation of neuroendocrine systems, particularly those involving the hypothalamic-pituitary-adrenal (HPA) axis. By studying its effects on hormone secretion, stress adaptation, and autonomic function, scientists gain valuable knowledge about the integrative role of orexinergic signaling in coordinating physiological responses to internal and external stimuli. Such research advances the understanding of how neural and hormonal networks interact to maintain homeostasis under varying conditions.
In summary, Orexin A, human, is a versatile compound that underpins a wide spectrum of scientific inquiries across neuroscience, sleep research, metabolism, behavioral science, and neuroendocrinology. Its use in experimental protocols continues to expand the frontiers of knowledge regarding brain function and systemic regulation, reinforcing its status as an indispensable resource for academic and translational research.
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