Taltirelin is a thyrotropin-releasing hormone (TRH) analog, which mimics the physiological actions of TRH, but with a much longer half-life and duration of effects.

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Synonyms/Aliastaltirelin hydrate; (1-methyl-4,5-dihydroorotyl)-histidyl-prolinamide; TA-0910; TA 0910; LS-118853
Sequence(1-methyl-4,5-dihydroorotyl)- His-Pro-NH2
Labeling TargetThyrotropin-releasing hormone (TRH) receptors
ApplicationTaltirelin (marketed under the tradename Ceredist) has nootropic, neuroprotective and analgesic effects.
Biological ActivityTaltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release).
Areas of InterestNeurological Disease
DiseaseSpinocerebellar disease
TargetThyroid Hormone Receptor
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