Acetyl Hexapeptide-38 is a synthetic peptide composed of six amino acids, designed for use in cosmetic formulations targeting skin appearance. This ingredient is valued for its role in supporting skin conditioning and enhancing the overall look of skin texture. Compatible with a variety of delivery systems, Acetyl Hexapeptide-38 can be incorporated into serums, creams, and emulsions intended for daily skincare applications.
CAT No: HB00129
CAS No:1400634-44-7
Synonyms/Alias:Adifyline;1400634-44-7;Acetyl Hexapeptide-38;(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-hydroxybutanoic acid;Acetylhexapeptide-38;Acetyl-hexapeptide-38;UNII-XUJ27AR5LA;XUJ27AR5LA;BETZBTCJWHBFIG-JAAOUQFMSA-N;HY-P5225;AKOS040759588;PD159354;CS-0863723;N-Acetyl--L-seryl-L-valyl-L-valyl-L-valyl-L-arginyl-L-threonine;(2S,3R)-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-methylbutanamido]-3-methylbutanamido]-3-methylbutanamido]pentanamido]-3-hydroxybutanoic acid;
Mechanism of Action (MOA)
Acetyl Hexapeptide-38 is a synthetic signal peptide that interacts with cellular pathways involved in lipid metabolism and extracellular matrix support. It is believed to modulate the expression of key proteins such as PGC-1α and adiponectin within adipocytes, thereby influencing signaling cascades related to lipid storage and cellular architecture. This peptide's activity may help optimize the physiological environment of the skin, supporting its overall appearance and texture.
Acetyl Hexapeptide-38 is suitable for incorporation into a variety of cosmetic formulations. Suggested application directions include:
- Add to facial serums for targeted skin care routines- Incorporate into emulsions such as creams and lotions- Use in leave-on masks and overnight treatments- Blend into eye contour products- Formulate within ampoules and single-use sachets- Include in lightweight gel-based systems
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More