Bradykinin is a physiologically and pharmacologically active peptide of the kinin group of proteins, consisting of nine amino acids.
CAT No: 10-101-72
CAS No:6846-03-3
Synonyms/Alias:Bradykinin acetate salt;6846-03-3;Bradykinin Acetate;BRADYKININ, ACETATE SALT, 98;acetic acid;(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid;H 1970; (S)-2-((S)-2-((S)-1-((S)-2-((S)-2-(2-((S)-1-((S)-1-((S)-2-Amino-5-guanidinopentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamido)acetamido)-3-phenylpropanamido)-3-hydroxypropanoyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-5-guanidinopentanoic Acid;L-BRADYKININ; ACETIC ACID;VIGBULRGBBKXHS-MIEKKPBHSA-N;MFCD06763566;AS-78097;PD018630;E78596;Bradykinin acetate (H-L-Arg-L-Pro-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg-OH.CH3CO2H);
Chemical Name:acetic acid;(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Bradykinin Acetate is a synthetic peptide derivative widely recognized for its role as a potent vasoactive mediator in the kallikrein-kinin system. As a nonapeptide, it is structurally composed of nine amino acids and is commonly supplied in its acetate salt form to enhance stability and solubility for laboratory applications. Bradykinin itself is a critical endogenous peptide involved in numerous physiological processes, most notably in the regulation of blood vessel dilation, smooth muscle contraction, and inflammatory responses. Due to its well-characterized receptor interactions and signaling pathways, Bradykinin Acetate serves as a valuable standard and research tool in the fields of cardiovascular, neurobiological, and inflammatory studies.
Receptor Pharmacology: Bradykinin Acetate is extensively utilized in receptor pharmacology to investigate the functional properties of bradykinin B1 and B2 receptors. By enabling precise activation or inhibition of these G protein-coupled receptors in cellular and tissue-based assays, the peptide facilitates detailed mapping of receptor signaling cascades, ligand specificity, and downstream physiological effects. Such studies are essential for elucidating the molecular underpinnings of vascular tone regulation, pain perception, and inflammatory signaling, thereby advancing basic and translational research in these domains.
Signal Transduction Studies: The compound is a preferred agonist for dissecting intracellular signaling mechanisms triggered by bradykinin receptor engagement. Application of Bradykinin Acetate in cultured endothelial cells, smooth muscle preparations, or neuronal systems allows researchers to characterize calcium mobilization, nitric oxide production, and secondary messenger pathways. These investigations provide critical insights into how bradykinin modulates endothelial permeability, vasodilation, and neurogenic inflammation, supporting the development of new hypotheses regarding cell signaling dynamics.
Inflammation and Vascular Biology Research: Due to its capacity to induce vasodilation and increase vascular permeability, Bradykinin Acetate is an indispensable tool in experimental models of inflammation and vascular biology. It is routinely used to simulate inflammatory responses, assess edema formation, and evaluate the interplay between kinins and other inflammatory mediators. Utilizing the peptide in ex vivo tissue assays or in vitro cell culture systems enables precise quantification of inflammatory endpoints and helps delineate the molecular interactions governing vascular responses to injury or infection.
Peptide Structure-Activity Relationship (SAR) Analysis: As a well-defined peptide ligand, Bradykinin Acetate is frequently employed as a reference standard in structure-activity relationship studies. By comparing its biological activity with that of synthetic analogs or modified peptides, researchers can identify critical residues responsible for receptor binding and activation. These SAR analyses inform peptide design strategies, aid in the discovery of novel kinin receptor modulators, and contribute to a deeper understanding of peptide-receptor interactions at the molecular level.
Analytical and Assay Development: The synthetic peptide is also valuable in the development and validation of analytical methods such as high-performance liquid chromatography (HPLC), mass spectrometry, and immunoassays. Serving as a calibration standard or positive control, Bradykinin Acetate enables accurate quantification, detection, and characterization of kinins and related peptides in complex biological matrices. These applications are essential for quality control, pharmacokinetic studies, and the establishment of robust assay platforms in biochemical research.
Collectively, the multifaceted utility of Bradykinin Acetate underscores its importance in peptide research, receptor biology, and analytical science. Its well-characterized pharmacological profile and reliable performance in experimental systems make it a preferred choice for investigators seeking to elucidate the diverse roles of kinins in health and disease at the molecular, cellular, and systems levels.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More