Cyclosporin A

Cyclosporin A is a cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It can bind to the cyclophilin and then inhibits calcineurin. Thus, it is widely used in organ transplantation to prevent rejection.

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Synonyms/AliasCyclosporine; Ciclosporin; Cyclosporin; Cyclosporin A; Cyclosporine A; Neoral; OL 27-400; Restasis; Sandimmun; Sandimmune
Chemical Name(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Labeling TargetPeptidyl-prolyl cis-trans isomerase A;
Calcium signal-modulating cyclophilin ligand;
Calcineurin subunit B type 2;
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
ApplicationFor prevention or treatment of organ (kidney, liver, and heart) transplant and tissue transplant rejection, rheumatoid arthritis, severe psoriasis.
Appearancewhite solid powder
Purity>98% (or refer to the Certificate of Analysis)
Biological ActivityCyclosporin A (Cyclosporine A, Cyclosporine, Ciclosporin, CsA) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.
Areas of InterestInflammation/Immunology
FunctionsCalcium ion binding;
Virion binding;
Peptidyl-prolyl cis-trans isomerase activity
DiseasePrevention of Cardiac Transplant Rejection;
Prevention of Liver Transplant Rejection;
Prevention of Kidney Transplant Rejection
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