Diprotin A

Diprotin A is a tripeptide inhibitor used to study protease specificity, particularly in X-Pro cleavage systems. Its compact sequence facilitates kinetic evaluation of enzyme-substrate interactions. Researchers analyze its binding profile to understand inhibitory patterns. The molecule supports mechanistic enzymology research.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Diprotin A(CAS 90614-48-5)

CAT No: D1503

CAS No:90614-48-5

Synonyms/Alias:diprotin A;90614-48-5;Ile-Pro-Ile;isoleucylprolylisoleucine;isoleucyl-prolyl-isoleucine;l-isoleucyl-l-prolyl-l-isoleucine;N-(1-L-Isoleucyl-L-prolyl)-L-isoleucine;MFCD00038707;CHEMBL214381;L-Isoleucine, N-(1-L-isoleucyl-L-prolyl)-;(2S,3S)-2-((S)-1-((2S,3S)-2-Amino-3-methylpentanoyl)pyrrolidine-2-carboxamido)-3-methylpentanoic acid;(2S,3S)-2-[[(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid;(2S,3S)-2-((((2S)-1-((2S,3S)-2-amino-3-methylpentanoyl)pyrrolidin-2-yl)(hydroxy)methylidene)amino)-3-methylpentanoate;(2S,3S)-2-(((2S)-1-((2S,3S)-2-amino-3-methylpentanoyl)pyrrolidine-2-carbonyl)amino)-3-methylpentanoic acid;(2S,3S)-2-({[(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino)-3-methylpentanoate;Spectrum2_001480;Spectrum3_001838;Diprotin A (Ile-Pro-Ile);BSPBio_003515;SPBio_001439;SCHEMBL6404766;BCBcMAP01_000164;CHEBI:93213;KBio3_003020;Dipeptidyl peptidase IV inhibitor;DTXSID80920277;BDBM50229666;CCG-38872;AKOS030210980;FD22530;SMP1_000085;NCGC00178015-01;Diprotin A (H-L-Ile-L-Pro-L-Ile-OH);MS-25221;HY-111174;CS-0034521;G12104;BRD-K69032158-001-02-2;Q27164930;N-[Hydroxy(1-isoleucylpyrrolidin-2-yl)methylidene]isoleucine;L-Isoleucyl-L-prolyl-L-isoleucine;N-(1-L-Isoleucyl-L-prolyl)-L-isoleucine;Ile-Pro-Ile;(2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-methylpentanoyl)pyrrolidine-5-carboxamido)-3-methylpentanoic acid;(2S,3S)-2-[[[(2S)-1-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]-2-pyrrolidinyl]-oxomethyl]amino]-3-methylpentanoic acid;(2S,3S)-2-{[(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidin-2-yl]formamido}-3-methylpentanoic acid;IPI;

Chemical Name:(2S,3S)-2-[[(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C17H31N3O4
M.W/Mr.
341.4
Sequence
One Letter Code:IPI
Three Letter Code:H-Ile-Pro-Ile-OH
Application
Diprotin A has been used as a supplement for blood collection for hormone measurement and used in Islets cell culture to stabilize glucagon-like peptide-1 (GLP-1). It has also been used to inhibit the breakdown of gonadotropin-inhibitory hormone (GnIH) following serum collection.
Purity
≥97% (HPLC)
Long-term Storage Conditions
Soluble to 100 mM in water
Shipping Condition
Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
InChI
InChI=1S/C17H31N3O4/c1-5-10(3)13(18)16(22)20-9-7-8-12(20)15(21)19-14(17(23)24)11(4)6-2/h10-14H,5-9,18H2,1-4H3,(H,19,21)(H,23,24)/t10-,11-,12-,13-,14-/m0/s1
InChI Key
JNTMAZFVYNDPLB-PEDHHIEDSA-N
Canonical SMILES
CCC(C)C(C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)O)N
Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)O)N

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