Heparin Binding Peptide is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin.
CAT No: R1353
CAS No:125720-21-0
Synonyms/Alias:Fibronectin Adhesion-promoting Peptide;125720-21-0;Heparin binding peptide;FIBRONECTINADHESION-PROMOTINGPEPTIDE;SCHEMBL3089699;(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoic acid;Fibronectin Adhesion-Promoting Peptide trifluoroacetate salt;DTXSID90430998;HY-P0306;DA-63438;FF108476;MS-31873;G12527;Fibronectin Adhesion-promoting Peptide, >=95% (HPLC);H-Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile-OH; H-WQPPRARI-OH;
Fibronectin Adhesion-promoting Peptide is a synthetic peptide derived from the cell-binding domain of fibronectin, a high-molecular-weight glycoprotein found in the extracellular matrix and plasma. This peptide is designed to mimic the bioactive sequences of fibronectin, particularly the RGD (Arg-Gly-Asp) motif, which is recognized by integrin receptors on the cell surface. As a result, it plays a pivotal role in mediating cell adhesion, migration, and signaling, making it a valuable research tool in cell biology, tissue engineering, and biomaterials development. Its ability to facilitate specific cell-matrix interactions underpins its widespread use in studies of cellular behavior, matrix biology, and the development of functionalized surfaces.
Cell Adhesion Studies: The fibronectin-derived peptide is extensively utilized to investigate the molecular mechanisms underlying cell adhesion. By providing a defined substrate that selectively interacts with integrin receptors, researchers can dissect the contributions of specific adhesion motifs to cellular attachment, spreading, and signaling. This approach enables controlled studies of integrin-mediated adhesion processes, supporting the elucidation of downstream signaling pathways and cytoskeletal organization in various cell types, including fibroblasts, endothelial cells, and stem cells.
Surface Functionalization for Biomaterials: In the field of biomaterials science, the adhesion-promoting peptide is employed to modify the surface properties of polymers, hydrogels, and other scaffolds. Covalent or non-covalent attachment of the peptide to material surfaces enhances their bioactivity by promoting selective cell attachment and spreading. Such functionalization strategies are critical for the development of advanced tissue engineering scaffolds, implant coatings, and biosensors, where robust and specific cell-material interactions are essential for device performance and biocompatibility.
Cell Migration and Wound Healing Assays: The peptide serves as a fundamental component in in vitro cell migration assays, such as scratch wound or transwell migration studies. By providing a consistent and biologically relevant adhesive cue, it facilitates reproducible analysis of cell motility, chemotaxis, and collective migration behaviors. These assays are instrumental in uncovering the regulatory factors that govern tissue repair, morphogenesis, and tumor cell invasion, thereby advancing knowledge in developmental biology and cancer research.
Signal Transduction Analysis: Researchers leverage the peptide's integrin-binding properties to probe the activation of intracellular signaling cascades initiated by cell-matrix interactions. By engaging specific integrin subtypes, the peptide enables controlled activation of pathways such as focal adhesion kinase (FAK), MAPK, and PI3K/Akt, which are central to cell survival, proliferation, and differentiation. This targeted approach supports mechanistic studies of how extracellular cues are transduced into cellular responses, offering insights into the regulation of gene expression and cellular phenotype.
Coating of Cell Culture Surfaces: The adhesion-promoting peptide is widely used to coat tissue culture plates, flasks, and microfluidic devices to improve cell attachment and viability in vitro. Compared to full-length fibronectin, the use of defined peptide sequences minimizes variability and enables the creation of highly controlled culture environments. This application is particularly advantageous for the expansion and maintenance of sensitive or primary cell types, as well as for high-throughput screening platforms where reproducibility and specificity of cell adhesion are paramount.
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