Goserelin

Goserelin, renowned for its synthetic nature, stands as a quintessential hormone deployed within the biomedicine industry, efficaciously combatting a myriad of hormone-responsive malignancies encompassing prostate and breast cancer. Its mechanism of action materializes through the tenacious inhibition of specific hormone synthesis, thus auspiciously subjugating the unbridled expansion of tumor cells while additionally alleviating consequential manifestations.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R2019

CAS No:65807-02-5

Synonyms/Alias:goserelin;65807-02-5;Zoladex;Decapeptide I;Goserelina;Gosereline;Goserelinum;ICI 118630;ICI-118630;UNII-0F65R8P09N;Goserelinum [Latin];ICI 118,630;HSDB 7606;0F65R8P09N;D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH;DTXSID7048297;Goserelinum (Latin);GOSERELIN (MART.);GOSERELIN [MART.];1-(5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-L-prolyl)semicarbazide;1233494-97-7;GOSERELIN (EP MONOGRAPH);GOSERELIN [EP MONOGRAPH];(2S)-1-[(2S)-2-[(2S)-2-[(2R)-3-(TERT-BUTOXY)-2-[(2S)-2-[(2S)-3-HYDROXY-2-[(2S)-2-[(2S)-3-(1H-IMIDAZOL-4-YL)-2-{[(2S)-5-OXOPYRROLIDIN-2-YL]FORMAMIDO}PROPANAMIDO]-3-(1H-INDOL-3-YL)PROPANAMIDO]PROPANAMIDO]-3-(4-HYDROXYPHENYL)PROPANAMIDO]PROPANAMIDO]-4-METHYLPENTANAMIDO]-5-CARBAMIMIDAMIDOPENTANOYL]-N-(CARBAMOYLAMINO)PYRROLIDINE-2-CARBOXAMIDE;(S)-N-((6S,9S,12R,15S,18S,21S,24S)-21-((1H-indol-3-yl)methyl)-1-amino-12-(tert-butoxymethyl)-6-((S)-2-(2-carbamoylhydrazine-1-carbonyl)pyrrolidine-1-carbonyl)-15-(4-hydroxybenzyl)-18-(hydroxymethyl)-25-(1H-imidazol-4-yl)-1-imino-9-isobutyl-8,11,14,17,20,23-hexaoxo-2,7,10,13,16,19,22-heptaazapentacosan-24-yl)-5-oxopyrrolidine-2-carboxamide;Gosereline [French];Goserelina [Spanish];MFCD01747329;Goserelin [USAN:INN:BAN];goserelin-acetate;MFCD00867894;HS-2015;ZD-9393;GOSERELIN [INN];GOSERELIN [MI];Goserelin (USAN/INN);GOSERELIN [HSDB];GOSERELIN [USAN];GOSERELIN [WHO-DD];SCHEMBL8643;CHEBI:5523;GTPL3879;CHEMBL1201247;DTXCID2028272;SCHEMBL19712239;SCHEMBL20459194;L02AE03;HMS2089D16;AKOS015994653;AKOS030213245;DB00014;NCGC00390804-01;FS110042;HY-13673;[D-Ser(tBu)6,Azagly10]-LHRH acetate salt;NS00120430;(D-Ser(tBu)6,Azagly10)-LHRH (free base);D04405;AB01275466-01;EN300-7480905;Q1992653;BRD-K99504665-001-01-2;6-(O-(1,1-Dimethylethyl)-D-serine)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig) 2-(aminocarbonyl)hydrazide;

Chemical Name:(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C59H84N18O14
M.W/Mr.
1269.4
Sequence
One Letter Code:XHWSYXLRP
Three Letter Code:H-Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHNHCONH2
InChI
InChI=1S/C59H84N18O14/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90)/t38-,39-,40-,41-,42-,43-,44-,45+,46-/m0/s1
InChI Key
BLCLNMBMMGCOAS-URPVMXJPSA-N
Canonical SMILES
CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(=O)N)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6
Isomeric SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NNC(=O)N)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6

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