Furin Inhibitor II

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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ExplanationHexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo.
SequenceOne Letter Code: RRRRRR (Modifications: Arg-6 = C-terminal amide, Arg-1,2,3,4,5,6=D-Arg)    
Three Letter Code: H-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2
Purity98% by HPLC
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