MTP-131; RX-31; SS-31 Elamipretide

Name: MTP-131; RX-31; SS-31 Elamipretide
Brand: Creative Peptides
SKU: R1809
Availability: MadeToOrder

Elamipretide is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide under the development of Stealth BioTherapeutics. It can Improve left Ventricular and Mitochondrial Function. Elamipretide can alleviate mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. It can prevent both iHTM and GTM(3) cells from sustained oxidative stress induced by H(2)O(2). Phase II clinical trials for the treatment of Chronic heart failure and Mitochondrial myopathies are ongoing.

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MTP-131; RX-31; SS-31 Elamipretide(CAS 736992-21-5)

CAT No: R1809

CAS No: 736992-21-5

Synonyms/Alias: Elamipretide;736992-21-5;bendavia;SS-31 peptide;Arg-Dmt-Lys-Phe-NH2;SS31 peptide;MTP-131;D-Arg-Dmt-Lys-Phe-NH2;UNII-87GWG91S09;Ocuvia;Elamipretide [USAN:INN];MTP 131;L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-;Szeto-schiller peptide;SS-31;Nh2-d-arg-dmt-lys-phe-nh2;MTP131;87GWG91S09;RX-31;(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide;(S)-6-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((R)-2-amino-5-guanidinopentanamido)-3-(4-hydroxy-2,6-dimethylphenyl)propanamido)hexanamide;Elamipretide [INN];Elamipretida;Elamipretide (USAN/INN);ELAMIPRETIDE [USAN];Elamipretide (MTP-131);ELAMIPRETIDE [WHO-DD];arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide;RX31;SS31;CHEMBL3833370;SCHEMBL15028020;DTXSID50471988;BDBM627985;D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide;D-Arg-Dmt-Lys-Phe-NH2;SS-31;EX-A7058;HY-P0125;MTP-131;MTP 131;MTP131;Bendavia;RX-31;(S)-6-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((R)-2-amino-5-guanidinopentanamido)-3-(4-hydroxy-2,6-dimethylphenyl)propanamido)hexanamide;s9803;AKOS027326652;CS-5846;DB11981;CVD-0019440;DA-63147;NS00072504;D10925;D78262;Q27269822;

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C32H49N9O5
M.W/Mr.	639.8
Sequence	One Letter Code:RXKF Three Letter Code:H-D-Arg-Tyr(2,6-diMe)-Lys-Phe-NH2
Activity	Inhibitor
Biological Activity	Elamipretide, also known as MTP-131 or D-Arg-Dmt-Lys-Phe-NH2,is a cardiolipin peroxidase inhibitor and mitochondria-targeted peptide. MTP-131 alleviates mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. MTP-131 could prevent both iHTM and GTM(3) cells from sustained oxidative stress induced by H(2)O(2).
Target	Cardiolipin Peroxidase

Shipping Condition	Room temperature in continental US; may vary elsewhere.
InChI	InChI=1S/C32H49N9O5/c1-19-15-22(42)16-20(2)23(19)18-27(41-29(44)24(34)11-8-14-38-32(36)37)31(46)39-25(12-6-7-13-33)30(45)40-26(28(35)43)17-21-9-4-3-5-10-21/h3-5,9-10,15-16,24-27,42H,6-8,11-14,17-18,33-34H2,1-2H3,(H2,35,43)(H,39,46)(H,40,45)(H,41,44)(H4,36,37,38)/t24-,25+,26+,27+/m1/s1
InChI Key	SFVLTCAESLKEHH-WKAQUBQDSA-N

1. Myotropic activity and immunolocalization of selected neuropeptides of the burying beetle Nicrophorus vespilloides (Coleoptera: Silphidae)

2. Odorant binding protein based biomimetic sensors for detection of alcohols associated with Salmonella contamination in packaged beef

3. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists

4. P-selectin and Complement’s Role in a Neonatal Model of Germinal Matrix Hemorrhage-Induced Secondary Injury

5. The effect of B-type allatostatin neuropeptides on crosstalk between the insect immune response and cold tolerance

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