(R)-MG132

(R)-MG132 is a potent, reversible, and cell-permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
(R)-MG132(CAS 1211877-36-9)

CAT No: R1874

CAS No:1211877-36-9

Synonyms/Alias:(R)-MG132;1211877-36-9;(R)-MG-132;Benzyl n-[(2s)-4-methyl-1-[[(2r)-4-methyl-1-[[(2s)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate;MFCD28580122;Cbz-L-leu-D-leu-L-leu-H;CHEMBL1090713;SCHEMBL14579851;CHEBI:191090;EX-A7448;HY-13259C;s8410;AKOS030210983;CID 45103781;DA-65432;CS-0021842;MG-132(R), >=95% (HPLC);D-leucinamide, n-[(phenylmethoxy)carbonyl]-l-leucyl-n-[(1s)-1-formyl-3-methylbutyl]-;benzyl N-[(1S)-3-methyl-1-{[(1R)-3-methyl-1-{[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}butyl]carbamoyl}butyl]carbamate;Benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate; (R)-MG-132;

Chemical Name:benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

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cGMP Peptide
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  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C26H41N3O5
M.W/Mr.
475.6
Sequence
One Letter Code:LLL
Three Letter Code:Cbz-Leu-D-Leu-Leu-al
Purity
≥97% by HPLC
Activity
Potent 20S proteasome inhibitor (IC50 = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro.
Long-term Storage Conditions
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Shipping Condition
Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
InChI
InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1
InChI Key
TZYWCYJVHRLUCT-ZRBLBEILSA-N
Canonical SMILES
CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES
CC(C)C[C@@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1

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