(R)-MG132

Name: (R)-MG132
Brand: Creative Peptides
SKU: R1874
Availability: MadeToOrder

(R)-MG132 is a potent, reversible, and cell-permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively.

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CAT No: R1874

CAS No: 1211877-36-9

Synonyms/Alias: (R)-MG132;1211877-36-9;(R)-MG-132;Benzyl n-[(2s)-4-methyl-1-[[(2r)-4-methyl-1-[[(2s)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate;MFCD28580122;Cbz-L-leu-D-leu-L-leu-H;CHEMBL1090713;SCHEMBL14579851;CHEBI:191090;EX-A7448;HY-13259C;s8410;AKOS030210983;CID 45103781;DA-65432;CS-0021842;MG-132(R), >=95% (HPLC);D-leucinamide, n-[(phenylmethoxy)carbonyl]-l-leucyl-n-[(1s)-1-formyl-3-methylbutyl]-;benzyl N-[(1S)-3-methyl-1-{[(1R)-3-methyl-1-{[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}butyl]carbamoyl}butyl]carbamate;Benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate; (R)-MG-132;

Chemical Name: benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C26H41N3O5
M.W/Mr.	475.6
Sequence	One Letter Code:LLL Three Letter Code:Cbz-Leu-D-Leu-Leu-al
Purity	≥97% by HPLC
Activity	Potent 20S proteasome inhibitor (IC50 = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro.

Long-term Storage Conditions	Soluble to 100 mM in DMSO and to 20 mM in ethanol
Shipping Condition	Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
InChI	InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1
InChI Key	TZYWCYJVHRLUCT-ZRBLBEILSA-N
Canonical SMILES	CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES	CC(C)C[C@@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1

2. Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics

3. Effect of Probiotic Lactobacillus plantarum on Streptococcus mutans and Candida albicans Clinical Isolates from Children with Early Childhood Caries

4. C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients

5. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis

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