(R)-MG132 is a potent, reversible, and cell-permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively.

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Chemical Namebenzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
SequenceOne Letter Code: Cbz-LLL
Three Letter Code: Cbz-Leu-D-Leu-Leu-al
Purity≥97% by HPLC
ActivityPotent 20S proteasome inhibitor (IC50 = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro.
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