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Secretin (porcine) Hydrochloride

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RG 1068; RG1068; RG-1069; Secretin
17034-35-4 (net)
H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2 hydrochloride salt
Molecular Formula
Long-term Storage Conditions
Secretin has been widely used in medical field especially in pancreatic functioning test, since it promotes the normal growth and maintenance of the pancreas. Secretin also plays a role in the regulation of body water homeostasis and food intake.
Secretin stimulates the secretion of bicarbonate by the pancreas and inhibits the gastrin and acid production in the stomach. It also potentiates the release of digestive enzymes from the pancreas triggered by cholecystokinin.
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Diseases diagnosis
  • Background
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Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands. In humans, the secretin peptide is encoded by the SCT gene.

CAS: 5534-95-2
Sequence: Boc-β-Ala-Trp-Met-Asp-Phe-NH2
M.W: 767.9
Molecular Formula: C37H49N7O9S
CAS: 66104-23-2
Sequence: ---
M.W: 410.59
Molecular Formula: C20H30N2O3S2
CAS: 33507-63-0 (net)
Sequence: H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate salt
M.W: 1347.63
Molecular Formula: C63H98N18O13S
CAS: 77591-33-4 (net)
Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH acetate salt
M.W: 4963.49
Molecular Formula: C212H350N56O78S
CAS: 444-27-9
Sequence: H-DL-Thz-OH
M.W: 133.17
Molecular Formula: C4H7NO2S

Gastric acid secretion is under nervous and hormonal control. Gastrin, the major circulating stimulus of acid secretion, probably does not stimulate the parietal cells directly but acts to mobilize histamine from the ECL cells in the oxyntic mucosa. Histamine stimulates the parietal cells to secrete HCl. The gastrin-ECL cell pathway has been investigated extensively in situ (gastric submucosal microdialysis), in vitro (isolated ECL cells) and in vivo (intact animals). Gastrin acts on CCK2 receptors to control the synthesis of ECL-cell histamine, accelerating the expression of the histamine-forming enzyme histidine decarboxylase (HDC) at both the transcription and the translation/posttranslation levels. Depletion of histamine by alpha-fluoromethylhistidine (an irreversible inhibitor of HDC) prevents gastrin-induced but not histamine-induced gastric acid secretion. Acute CCK2 receptor blockade inhibits gastrin-evoked but not histamine-induced acid secretion. Studies both in vivo/in situ and in vitro have suggested that while acetylcholine seems capable of activating parietal cells, it does not affect histamine secretion from ECL cells. Unlike acetylcholine, the neuropeptides pituitary adenylate cyclase-activating peptide and vasoactive intestinal peptide mobilize ECL-cell histamine. Whether vagally stimulated acid secretion reflects an effect of the enteric nervous system on the ECL cells (neuropeptides) and/or a direct one on the parietal cells needs to be further investigated.

Lindström, E., Chen, D., Norlén, P., Andersson, K., & Håkanson, R. (2001). Control of gastric acid secretion: the gastrin-ECL cell-parietal cell axis. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 128(3), 503-511.

Our understanding of secretin and pancreatic secretions has developed. However, the salient findings of Bayliss and Starling concerning secretin have stood the test of time. Thus secretin is recognized as the key pathway mediating a now classical negative feedback reflex. Acidic chyme, emptying from the stomach, stimulates upper small intestinal mucosal S cells to release secretin. Secretin stimulates the flow of a bicarbonate-rich pancreatic secretion which empties into the duodenum, thus neutralizing the acid chime and removing the stimulus for secretin release. Of wider significance, the concept of hormonal regulation and the definition of a hormone basically remain to this day as originally outlined in Starling’s Croonian Lectures.

Hirst, B. H. (2004). Secretin and the exposition of hormonal control. The Journal of physiology, 560(2), 339-339.

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