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Sinapultide

CAT#
10-101-168
Synonyms/Alias
ATI 01; 138531-07-4; KL4 (peptide);
CAS No.
138531-07-4
Sequence
H-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-OH
M.W/Mr.
2469.39892
Molecular Formula
C126H238N26O22
Source
Synthetic
Application
Intended for the prevention of respiratory distress syndrome (RDS) in premature infants at high risk for RDS.
Description
Lucinactant is a new synthetic peptide-containing surfactant for intratracheal use. It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units, KL4 peptide) designed to mimic human surfactant protein-B (SB-P). More specifically, it mimics the C-terminal amphipathic helical domain of this protein. It also consists of phospholipids (dipalmitoylphosphatidylcholine, DPPC and palmitoyloleoyl phosphatidylglycerol, POPG) and a fatty acid (palmitic acid). It is completely devoid of animal-derived components.
Areas of Interest
Respiratory distress syndrome (RDS)
Storage
-20°C

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