Sinapultide
Lucinactant is a new synthetic peptide-containing surfactant for intratracheal use. It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units, KL4 peptide) designed to mimic human surfactant protein-B (SB-P). More specifically, it mimics the C-terminal amphipathic helical domain of this protein. It also consists of phospholipids (dipalmitoylphosphatidylcholine, DPPC and palmitoyloleoyl phosphatidylglycerol, POPG) and a fatty acid (palmitic acid). It is completely devoid of animal-derived components.
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| CAT# | 10-101-168 |
| CAS | 138531-07-4 |
| Synonyms/Alias | ATI 01; 138531-07-4; KL4 (peptide); |
| M.F/Formula | C126H238N26O22 |
| M.W/Mr. | 2469.39892 |
| Sequence | KLLLLKLLLLKLLLLKLLLLK |
| Labeling Target | Lung epithelial cells |
| Application | Intended for the prevention of respiratory distress syndrome (RDS) in premature infants at high risk for RDS. |
| Activity | Agonist |
| Biological Activity | Sinapultide is a synthetic peptide used to mimic human lung surfactant protein B, the most important surfactant protein for a proper functioning of the respiratory system. |
| Areas of Interest | Respiratory System & Disease |
| Disease | Respiratory distress syndrome in the newborn |
| Source# | Synthetic |
Storage | -20°C |
Organism | Human |
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