Somatostatin is a tetradecapeptide which can suppress the growth hormone (GH) secretion and control the pituitary hormone secretion in human CNS.
CAT No: 10-101-32
CAS No:38916-34-6 (net), 51110-01-1 (acetate)
Synonyms/Alias:SOMATOSTATIN;38916-34-6;Cyclic Somatostatin;Somatostatina;Somatostatine;Somatostatin-14;Somatostatinum;Somatostatin, cyclic;Somatostatin (sheep);Somatostatin 14;Somatostatin acetate;Synthetic somatostatin-14;Somatostatin (rat);Aminopan;Somatostatine [INN-French];Somatostatinum [INN-Latin];Somatostatin (human);Somatostatina [INN-Spanish];Somatostatin (pigeon);CCRIS 3629;Somatostatin [INN:BAN];EINECS 254-186-5;Stilamin;SRIF 14;UNII-6E20216Q0L;MFCD00076762;SOMATOSTATIN [MI];SOMATOSTATIN [INN];SR 9357;SOMATOSTATIN [MART.];Somiaton;SOMATOSTATIN [WHO-DD];CHEBI:64628;SOMATOSTATIN [EP MONOGRAPH];Somatostatin (INN);SRIF;6E20216Q0L;Somatotropin release-inhibiting factor;Somatostatine (INN-French);Somatostatinum (INN-Latin);Somatostatina (INN-Spanish);SOMATOSTATIN (MART.);15-28-Somatostatin-28;CCRIS 7071;SOMATOSTATIN (EP MONOGRAPH);EINECS 256-969-7;Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys];L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide;L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide;DTXCID6026793;SRIH-14;Ala-Gly-cyclo-(Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys);Somatostatin-1;L-alanyl-N-((4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis((1R)-1-hydroxyethyl)-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl)glycinamide;Somatotropin release inhibiting factor;Recombinant Somatostatin;GH-RIH;Somatostatin-14 Acetate;CHEMBL1823872;SCHEMBL21361053;BDBM81767;H01CB01;AKOS015994634;AC-8931;DB09099;FS27855;HS-2027;NCGC00167137-01;CAS_38916-34-6;CB6417646;C74981;BRD-K14681867-001-01-6;BRD-K14681867-015-01-6;Q22075835;Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH(Cys3-Cys14);ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH,CYS-CYS;ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS 3,14-disulfide;254-186-5;256-969-7;Somatostatin-14 (H-L-Ala-L-Gly-L-Cys(1)-L-Lys-L-Asn-L-Phe-L-Phe-L-Trp-L-Lys-L-Thr-L-Phe-L-Thr-L-Ser-L-Cys(1)-OH);
Somatostatin Acetate is a synthetic peptide corresponding to the naturally occurring somatostatin, a regulatory neuropeptide with broad inhibitory effects on endocrine, neuroendocrine, and exocrine secretions. As a cyclic tetradecapeptide, it plays a pivotal role in modulating physiological processes such as hormone release, neurotransmission, and cellular signaling. Its biochemical significance lies in its ability to bind to somatostatin receptors, leading to the inhibition of growth hormone, insulin, glucagon, and various gastrointestinal peptides. The acetate salt form enhances its stability and solubility for laboratory handling, making it a valuable tool in peptide research and functional studies.
Receptor Binding Studies: Somatostatin Acetate is extensively utilized in receptor binding assays to characterize the pharmacological properties and distribution of somatostatin receptor subtypes (SSTRs) in various tissues. By serving as a reference ligand or competitive inhibitor, it allows researchers to delineate receptor-ligand interactions, assess receptor affinity, and investigate the downstream signaling pathways mediated by these G protein-coupled receptors. Such studies are fundamental for understanding the physiological roles of somatostatin in neuroendocrine regulation and for the development of receptor-specific analogs.
Peptide Functional Analysis: In the context of functional studies, this peptide is employed to probe the inhibitory mechanisms on hormone secretion in isolated cell systems or tissue preparations. Its application enables the dissection of somatostatin-mediated negative feedback loops, particularly in the pituitary, pancreas, and gastrointestinal tract. By modulating the release of growth hormone, insulin, and other peptides, it provides insights into the interplay between peptide hormones and their effects on metabolic and endocrine homeostasis.
Signal Transduction Research: Somatostatin Acetate serves as a model compound for examining intracellular signaling cascades triggered by somatostatin receptor activation. Researchers utilize it to study the inhibition of adenylyl cyclase, reduction of cyclic AMP levels, and modulation of ion channel activity. These investigations contribute to a deeper understanding of how neuropeptides regulate cellular excitability and secretory functions, as well as the potential cross-talk between different signaling pathways in neuronal and endocrine cells.
Peptide Synthesis and Analytical Calibration: The synthetic form of somatostatin is also valuable as a standard or reference material in peptide synthesis and analytical method development. Its well-characterized structure and bioactivity make it suitable for validating peptide purification protocols, optimizing chromatographic separation techniques, and calibrating mass spectrometric analyses. Such applications are essential for quality control and method validation in peptide research laboratories.
Endocrine and Neuroendocrine Research Models: As a prototypical inhibitory peptide, somatostatin acetate is frequently incorporated into in vitro and ex vivo experimental models to study the regulation of hormone secretion and neural signaling. Its use in these systems enables the elucidation of feedback mechanisms, paracrine and autocrine signaling, and the physiological consequences of somatostatin modulation in both central and peripheral tissues. These models are instrumental for advancing knowledge in neuroendocrinology and for exploring the functional diversity of peptide hormones.
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