Somatostatin is a tetradecapeptide which can suppress the growth hormone (GH) secretion and control the pituitary hormone secretion in human CNS.
CAT No: 10-101-32
CAS No:38916-34-6 (net), 51110-01-1 (acetate)
Synonyms/Alias:SOMATOSTATIN;38916-34-6;Cyclic Somatostatin;Somatostatina;Somatostatine;Somatostatin-14;Somatostatinum;Somatostatin, cyclic;Somatostatin (sheep);Somatostatin 14;Somatostatin acetate;Synthetic somatostatin-14;Somatostatin (rat);Aminopan;Somatostatine [INN-French];Somatostatinum [INN-Latin];Somatostatin (human);Somatostatina [INN-Spanish];Somatostatin (pigeon);CCRIS 3629;Somatostatin [INN:BAN];EINECS 254-186-5;Stilamin;SRIF 14;UNII-6E20216Q0L;MFCD00076762;SOMATOSTATIN [MI];SOMATOSTATIN [INN];SR 9357;SOMATOSTATIN [MART.];Somiaton;SOMATOSTATIN [WHO-DD];CHEBI:64628;SOMATOSTATIN [EP MONOGRAPH];Somatostatin (INN);SRIF;6E20216Q0L;Somatotropin release-inhibiting factor;Somatostatine (INN-French);Somatostatinum (INN-Latin);Somatostatina (INN-Spanish);SOMATOSTATIN (MART.);15-28-Somatostatin-28;CCRIS 7071;SOMATOSTATIN (EP MONOGRAPH);EINECS 256-969-7;Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys];L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide;L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide;DTXCID6026793;SRIH-14;Ala-Gly-cyclo-(Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys);Somatostatin-1;L-alanyl-N-((4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis((1R)-1-hydroxyethyl)-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl)glycinamide;Somatotropin release inhibiting factor;Recombinant Somatostatin;GH-RIH;Somatostatin-14 Acetate;CHEMBL1823872;SCHEMBL21361053;BDBM81767;H01CB01;AKOS015994634;AC-8931;DB09099;FS27855;HS-2027;NCGC00167137-01;CAS_38916-34-6;CB6417646;C74981;BRD-K14681867-001-01-6;BRD-K14681867-015-01-6;Q22075835;Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH(Cys3-Cys14);ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH,CYS-CYS;ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS 3,14-disulfide;254-186-5;256-969-7;Somatostatin-14 (H-L-Ala-L-Gly-L-Cys(1)-L-Lys-L-Asn-L-Phe-L-Phe-L-Trp-L-Lys-L-Thr-L-Phe-L-Thr-L-Ser-L-Cys(1)-OH);
Somatostatin Acetate, also known as SST or growth hormone-inhibiting hormone (GHIH), is a synthetic peptide that mirrors the structure and biological activity of endogenous somatostatin. As a key regulatory molecule, it exerts broad inhibitory effects on endocrine and exocrine secretions throughout the body. Its chemical stability and solubility make it suitable for a variety of research and experimental settings, especially in studies focused on hormonal regulation, signal transduction, and neuroendocrine processes. Researchers value Somatostatin Acetate for its ability to modulate multiple physiological pathways, providing a versatile tool for dissecting complex biological mechanisms in vitro and in vivo.
Endocrine Regulation: In hormone research, Somatostatin Acetate is widely employed to study the inhibition of growth hormone, insulin, and glucagon release from the pituitary and pancreatic islets. By acting as a potent suppressor of these hormones, it enables scientists to investigate feedback loops and regulatory networks involved in glucose metabolism, energy homeostasis, and growth factor signaling. Its use in experimental models helps clarify the intricate balance between stimulatory and inhibitory hormonal influences, offering insights into the pathophysiology of metabolic disorders and endocrine dysfunctions.
Neurobiology and Neuroscience: Within the realm of neurobiology, SST is utilized to explore its role as a neurotransmitter and neuromodulator in the central and peripheral nervous systems. It has been instrumental in mapping somatostatinergic pathways and understanding their involvement in synaptic transmission, neuronal excitability, and pain modulation. Studies employing Somatostatin Acetate facilitate the dissection of its effects on neuronal plasticity, memory formation, and neuroprotective mechanisms, contributing to a deeper understanding of brain function and neurological disease models.
Gastrointestinal Research: In gastrointestinal physiology, Somatostatin Acetate serves as a valuable agent for investigating the regulation of digestive secretions and motility. By inhibiting the release of gastric acid, pepsin, and other digestive enzymes, it provides a means to study the control of digestive processes and the interplay between the nervous and endocrine systems in the gut. Researchers use it to model conditions of dysregulated secretion, explore mucosal protection mechanisms, and analyze the impact of somatostatinergic signaling on gastrointestinal homeostasis.
Tumor Biology and Cell Proliferation: In cancer research, the peptide is applied to examine its antiproliferative effects on various tumor cell lines, particularly those expressing somatostatin receptors. Experimental data suggest that it can modulate cell cycle progression, induce apoptosis, and inhibit angiogenesis, making it a useful tool for probing the molecular mechanisms underlying tumor growth and metastasis. Its ability to target specific receptor subtypes has also enabled the development of receptor-binding assays and imaging techniques for tumor localization and characterization.
Immunological Studies: Somatostatin Acetate is increasingly recognized for its immunomodulatory properties, influencing cytokine production and immune cell activity. Researchers employ it to investigate the regulation of inflammatory responses, autoimmunity, and immune surveillance. Through its interactions with immune cells such as T lymphocytes and macrophages, SST provides a platform for exploring the crosstalk between the neuroendocrine and immune systems, advancing our understanding of immune regulation in health and disease.
Peptide analogs like Somatostatin Acetate continue to expand the toolkit available for fundamental and translational research. Its multifaceted biological actions, receptor specificity, and compatibility with diverse experimental systems make it an indispensable resource for advancing scientific inquiry in endocrinology, neurobiology, oncology, gastroenterology, and immunology. As ongoing research uncovers new somatostatin-mediated pathways and interactions, the applications of this compound are poised to grow, supporting discoveries that bridge molecular mechanisms with physiological outcomes.
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