Insulin Detemir is a long-lasting, recombinant version of human insulin. It is an insulin analogue with myristic acid bound to the lysine at position B29 and a deletion of B30.
CAT No: 10-101-333
CAS No:169148-63-4
Chemical Name:(2S)-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[(1R,6R,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,50S,53S,56S,59S,62S,65S,68S,71S,74R,77S,80S,83S,88R)-88-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[(2-aminoacetyl)amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]-6-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-5-oxopentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methylpentanoyl]amino]-47-[[(1S)-3-amino-1-carboxy-3-oxopropyl]carbamoyl]-53-(2-amino-2-oxoethyl)-62-(3-amino-3-oxopropyl)-77-[(2S)-butan-2-yl]-24,56-bis(2-carboxyethyl)-83-[(1R)-1-hydroxyethyl]-12,71,80-tris(hydroxymethyl)-33,50,65-tris[(4-hydroxyphenyl)methyl]-15-(1H-imidazol-4-ylmethyl)-27-methyl-18,30,36,59,68-pentakis(2-methylpropyl)-7,10,13,16,19,22,25,28,31,34,37,40,49,52,55,58,61,64,67,70,73,76,79,82,85,87-hexacosaoxo-21,39-di(propan-2-yl)-3,4,44,45,90,91-hexathia-8,11,14,17,20,23,26,29,32,35,38,41,48,51,54,57,60,63,66,69,72,75,78,81,84,86-hexacosazabicyclo[72.11.7]dononacontane-42-carbonyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-6-(tetradecanoylamino)hexanoic acid
Insulin detemir is a long-acting basal insulin analog designed to provide prolonged and consistent glycemic control. Characterized by its acylated structure, which facilitates strong albumin binding, this compound exhibits a predictable pharmacokinetic profile and extended duration of action compared to conventional human insulin. Insulin detemir is produced using recombinant DNA technology, ensuring high batch-to-batch consistency and reduced immunogenicity. Its unique molecular modifications enable a steady release into the bloodstream, minimizing fluctuations in plasma insulin levels and supporting stable metabolic regulation in various research models. Due to these properties, insulin detemir is highly valued in scientific investigations focused on carbohydrate metabolism, insulin signaling pathways, and endocrine system modulation.
Metabolic Research: Insulin detemir is extensively utilized in metabolic research to investigate the mechanisms underlying glucose homeostasis and insulin sensitivity. By providing a stable and predictable insulin effect, it allows researchers to accurately assess basal glucose turnover, hepatic glucose production, and peripheral glucose uptake in animal models and in vitro systems. Its consistent activity profile facilitates experiments requiring prolonged insulin exposure, such as studies on insulin resistance, metabolic syndrome, and obesity-related metabolic disturbances. The use of insulin detemir in these settings helps elucidate the molecular and physiological responses to sustained insulin action, thereby advancing the understanding of metabolic diseases and potential therapeutic targets.
Endocrine Physiology Studies: In the field of endocrine physiology, insulin detemir serves as a valuable tool for dissecting the roles of basal insulin in hormonal regulation and feedback mechanisms. Researchers employ it to examine how steady-state insulin levels influence the secretion and activity of counter-regulatory hormones such as glucagon, cortisol, and growth hormone. Its prolonged action makes it ideal for experiments requiring maintenance of stable insulin concentrations over extended periods, enabling detailed analysis of endocrine adaptations to chronic insulin exposure. These studies contribute to the knowledge of hormonal interplay in glucose regulation and energy balance.
Cell Signaling Investigations: The unique pharmacological properties of insulin detemir make it a preferred choice in cell signaling investigations, particularly those focused on the insulin receptor and downstream effectors. Scientists use it to stimulate insulin receptors in cultured cells, tissues, or animal models, enabling the study of signal transduction pathways such as PI3K/Akt and MAPK/ERK. The ability to provide sustained receptor activation without rapid degradation or fluctuations enhances experimental reproducibility and clarity in dissecting the temporal dynamics of insulin-mediated signaling events. Insights gained from these studies are instrumental in unraveling the complexities of insulin action at the cellular level.
Pharmacokinetic and Pharmacodynamic Modeling: Insulin detemir is frequently employed in pharmacokinetic and pharmacodynamic modeling to characterize its absorption, distribution, metabolism, and elimination profiles. Researchers utilize it to develop and validate mathematical models that predict insulin behavior in biological systems, supporting the optimization of dosing regimens and delivery methods. Its consistent and prolonged action provides a robust foundation for comparative studies with other insulin analogs, contributing to the refinement of basal insulin therapies and the development of novel delivery technologies. These modeling efforts are essential for advancing the science of insulin replacement and improving experimental design in diabetes research.
Comparative Efficacy Studies: Comparative efficacy studies benefit from the inclusion of insulin detemir as a reference compound when evaluating new insulin analogs or alternative therapeutic agents. Its well-characterized action profile and reproducibility make it an ideal comparator in preclinical experiments assessing glycemic control, metabolic outcomes, and safety parameters. By serving as a benchmark, it enables researchers to objectively measure the relative performance of investigational compounds, facilitating the identification of candidates with superior pharmacological attributes. These comparative analyses are critical for driving innovation in the field of insulin research and expanding the repertoire of tools available for metabolic investigation.
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