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Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.
| CAT# | GR1228 |
| Explanation | TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY also reduces the tubularization of hypoxic HUVECs. |
| M.F/Formula | C111H188N42O24S2 |
| M.W/Mr. | 2559.1 |
| Sequence | One Letter Code: CLLFVY CGRKKRRQRRRPPQ*(Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*) Three Letter Code: Cys-Leu-Leu-Phe-Val-Tyr-Cys-Gly-Arg-Lys-Lys-Gln-Arg-Arg-Arg-Pro-Pro-Gln |
| Purity | >98 % |
| Long-term Storage Conditions | Soluble to 1 mg/ml in water | Shipping Condition | +20°C (International: -20°C) | InChI Key | AWUUHEHYNQGEFC-XLZVTALKSA-N | Canonical SMILES | CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(C)C)CSSCC(C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)N2CCCC2C(=O)N3CCCC3C(=O)NC(CCC(=O)N)C(=O)O)N)CC4=CC=C(C=C4)O)C(C)C)CC5=CC=CC=C5 |
| CAT# | Product Name | M.W | Molecular Formula | Inquiry |
|---|---|---|---|---|
| GR1213 | R9-TAT | Inquiry | ||
| GR1205 | D-TAT (47-57) | Inquiry | ||
| GR1207 | TAT- C (48-57) | Inquiry | ||
| GR1214 | Tat-Beclin-1 | Inquiry | ||
| GR1230 | TAT-Gap19 | Inquiry |
* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).
