Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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ExplanationTAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY also reduces the tubularization of hypoxic HUVECs.
SequenceOne Letter Code: CLLFVY CGRKKRRQRRRPPQ*(Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*)
Three Letter Code: Cys-Leu-Leu-Phe-Val-Tyr-Cys-Gly-Arg-Lys-Lys-Gln-Arg-Arg-Arg-Pro-Pro-Gln
Purity>98 %
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