Anisomycin is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
CAT# | Z10-101-164 |
CAS | 22862-76-6 |
Background | Anisomycin, also known as flagecidin, is an antibiotic produced by Streptomyces griseolus which inhibits eukaryotic protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways. Anisomycin is inactive against bacteria. Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. >> Read More |
Synonyms/Alias | Flagecidin |
M.F/Formula | C14H19NO4 |
M.W/Mr. | 265.31 |
Labeling Target | c-Jun N-terminal kinase (JNK) |
Application | Anisomycin is used as a antineoplastic agent that inhibits or prevents the proliferation of neoplasms. |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Activity | Inhibitor |
Biological Activity | Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. Anisomycin is a JNK activator, which increases phospho-JNK. Anisomycin is a bacterial antibiotic. |
Areas of Interest | Immunology & Inflammation Cell Biology Cancer |
Functions | Anisomycin is inactive against bacteria. |
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