Anisomycin
Anisomycin is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
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| CAT# | Z10-101-164 |
| CAS | 22862-76-6 |
| Synonyms/Alias | Flagecidin |
| M.F/Formula | C14H19NO4 |
| M.W/Mr. | 265.31 |
| Labeling Target | c-Jun N-terminal kinase (JNK) |
| Application | Anisomycin is used as a antineoplastic agent that inhibits or prevents the proliferation of neoplasms. |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Activity | Inhibitor |
| Biological Activity | Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. Anisomycin is a JNK activator, which increases phospho-JNK. Anisomycin is a bacterial antibiotic. |
| Areas of Interest | Immunology & Inflammation
Cell Biology
Cancer |
| Functions | Anisomycin is inactive against bacteria. |
| Storage | −20°C |
Solubility | Soluble in DMSO |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Short-term Storage Conditions | Dry, dark and at 0 - 4 °C |
Long-term Storage Conditions | -20 °C |
Organism | Human |
InChI | InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1 |
InChI Key | YKJYKKNCCRKFSL-RDBSUJKOSA-N |
Isomeric SMILES | CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O |
BoilingPoint | 398.7±42.0 °C at 760 mmHg |
ShelfLife | >2 years if stored properly |
Melting Point | 140-141ºC |
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